肿瘤浸润淋巴细胞在三阴性乳腺癌中的浸润情况及意义

王艳; 许波; 刘先富

doi:10.13898/j.cnki.issn.1000-2200.2022.06.008

肿瘤浸润淋巴细胞在三阴性乳腺癌中的浸润情况及意义

Infiltration and significance of tumor infiltrating lymphocytes in triple negative breast cancer

摘要

摘要:
目的对三阴性乳腺癌（TNBC）病人原发灶癌巢和间质中的肿瘤浸润淋巴细胞（TILs）进行计数，分析TILs在TNBC中的浸润情况及其与临床预后的关系。
方法选取来自蚌埠医学院第一附属医院的TNBC病人45例，通过HE染色来计数TILs在原发灶癌巢和间质中的分布情况，根据相应的临床资料和病理特征分析TILs和临床预后之间的关系。
结果基质中TILs（STILs）、癌巢内TILs（ITILs）、整体TILs是TNBC病人总生存率（OS）和无病生存率（DFS）的保护因素，阳性淋巴结数目和临床分期是TNBC病人OS和DFS的危险因素。STILs、ITILs、TILs浸润水平越高病人预后越好。
结论STILs、ITILs、TILs是TNBC病人的独立预后影响因素。

Abstract:
ObjectiveTo count the tumor infiltrating lymphocytes(TILs) in the primary tumor nests and stroma in patients with triple negative breast cancer(TNBC), and analyze the infiltration of TILs in TNBC and its relationship with clinical prognosis.
MethodsForty-five patients with TNBC were selected from The First Affiliated Hospital of Bengbu Medical College. The expression of TILs in primary tumor nests and stroma were counted by HE staining, and the relationship between TILs and clinical prognosis was analyzed according to the corresponding clinical data and pathological features.
ResultsThe stromal TILs(STILs), intracellular TILs(ITILs) and global TILs were the protective factors of overall survival(OS) and disease-free survival(DFS) in TNBC patients. The number of positive lymph nodes and clinical stage were the risk factors of OS and DFS in TNBC patients. The higher the infiltration levels of STILs, ITILs and TILs were, the better the prognosis was.
ConclusionsThe levels of STILs, ITILs and TILs are the dependent prognostic factors in patients with TNBC.

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