ObjectiveTo compare the effects of toxin clearance between high-flux hemodialysis(HFHD) and hemodiafiltration(HDF) in uremia patients with chronic renal failure.

MethodsA total of uremia 122 patients with chronic renal failure were investigated.The patients were divided into the control group and observation group according to the time of the first dialysis.The observation group and control group were treated with HDF and HFHD, respectively.The toxin clearance effects were compared between two groups, and the application effects of two methods were analyzed.

ResultsThere was no statistical significance in the clearance rate of small molecule toxins between two groups(P>0.05).The large and medium molecule toxins clearance in two groups were improved after dialysis(P < 0.01), and the improvement in observation group was significantly better than that in control group(P < 0.01).There was no statistical significance in urea clearance time and standard protein catabolic rate index between two groups(P>0.05).The incidence rate of post-dialysis complications in observation group was significantly lower than those in control group(P < 0.01).

ConclusionsHFHD on clearance of large molecule toxins in uremia patients with chronic renal failure has better effects, can reduce the incidence rate of complications, and is worthy of clinical application.