淮北市人乳头状瘤病毒感染及其亚型分布特点

木朝宇; 张晓梅; 徐珍; 范德胜; 刘培明; 姚慧琳

doi:10.13898/j.cnki.issn.1000-2200.2022.11.024

淮北市人乳头状瘤病毒感染及其亚型分布特点

Human papillomavirus infection status and its subtype distribution in Huaibei city

摘要

摘要:
目的探讨淮北市宫颈人乳头状瘤病毒（HPV）感染状况及其亚型分布特点，为临床女性宫颈癌的防治提供参考依据。
方法收集2017年3月至2018年6月淮北矿工总医院筛查3 536例宫颈脱落细胞标本，采用PCR-反向点杂交法进行HPV基因亚型检测并进行统计分析。
结果3 536例样本中，阳性样本655例，检出率18.52%。单一亚型的感染率12.30%，明显高于多重感染率的6.22%（P<0.01）；高危亚型的感染率11.59%，明显高于低危亚型的3.62%和高低危混合型的3.31%（P<0.01）。不同年龄组，51~60岁组感染率最高（20.39%），单一感染与多重感染率差异有统计学意义（P<0.05）；41~50岁组阳性占比最高（单一：42.07%，多重：34.09%）。HPV优势亚型依次为52、16、58、44、40型。
结论淮北地区女性HPV感染率为18.52%，以单一高危型感染为主，HPV52、16、58是主要的感染亚型。41~60岁人群应作为临床重点筛查对象。

Abstract:
ObjectiveTo investigate the prevalence of human papillomavirus(HPV) and its subtype distribution in Huaibei city, and provide reference for the prevention and treatment of cervical cancer in clinical women.
MethodsFrom March 2017 to June 2018, 3 536 samples of cervical shedding cells were screened in Huaibei Miners General Hospital, and the gene subtypes of HPV were detected by PCR-reverse pot hybridization for statistical analysis.
ResultsAmong the 3 536 samples, 655 cases were positive samples, and the detection rate of which was 18.52%.The infection rate of single subtype(12.30%) was significantly higher than that of multiple infection rate(6.22%)(P<0.01).The infection rate of high-risk subtypes was 11.59%, which was significantly higher than that of low-risk subtypes(3.62%) and mixed high-risk subtypes(3.31%)(P<0.01).Among different age groups, the highest infection rate was found in the 51-60 age group(20.39%), and the difference between single infection and multiple infection rates was statistically significant(P<0.05).The positive rate of 41-50 years old group was the highest(single for 42.07%, multiple for 34.09%).The dominant subtypes of HPV were 52, 16, 58, 44 and 40 in turn.
ConclusionsThe HPV infection rate of women in Huaibei city is 18.52%, which is mainly caused by single high-risk infection.The HPV 52, 16, and 58 are the most common infection subtypes.The women aged 41-60 years are the key objects for HPV screening.

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