ObjectiveTo analyze the improvement effects of extract of Ginkgo biloba(EGB) on the schizophrenia model rats induced by dizocilpine(MK-801), and its mechanism.

MethodsForty clean male Sprague-Dawley(SD) adult rats were randomly divided into the blank group, model group, control group and experimental group(10 rats in each group). The blank group was intraperitoneally injected with 0.9% sodium chloride solution. The model group, control group and experimental group were intraperitoneally injected with MK-801. The control group was additionally injected with risperidone, while the experimental group was additionally treated with EGB. The serum levels of malondialdehyde(MDA) and superoxide dismutase(SOD), expression of glutamate(Glu) in frontal brain tissues, escape latency time and open field test parameters were compared among four groups.

ResultsCompared with the blank group, the MDA level was significantly higher, and the expression levels of SOD and Glu were significantly lower in model group(P < 0.05). Compared with the model group, the level of MDA was significantly lower, and the expression levels of SOD and Glu were significantly higher in the control group and experimental group(P < 0.01). Compared with the control group, the expression level of Glu was significantly higher in the experimental group(P < 0.01). On the first and second day of evaluation, the escape latency in model group, control group and experimental group were significantly longer than that in blank group(P < 0.05). On the third, fourth and fifth day of evaluation, the escape latency in control group and experimental group were significantly shorter than that in model group(P < 0.01). Compared with the blank group, the crossing frequency, central activity time ratio and central activity distance ratio in the model group significantly increased(P < 0.05). Compared with the model group, the crossing frequency, central activity time ratio and central activity distance ratio in the control group and experimental group significantly increased, and the differences of which were statistically significant(P < 0.01).

ConclusionsEGB can effectively relieve the schizophrenia caused by MK-801, promote the recovery of neurocognitive function, and decrease anxiety and fear, which is related to the reduction of MDA and SOD levels, inhibition of lipid peroxidation and correction of Glu dysfunction.