NLR和PLR对局部晚期宫颈癌病人接受根治性放疗预后评估的价值

张余飞; 刘云琴; 臧春宝; 尹琍

doi:10.13898/j.cnki.issn.1000-2200.2022.12.015

NLR和PLR对局部晚期宫颈癌病人接受根治性放疗预后评估的价值

Prognostic value of NLR and PLR in patients with locally advanced cervical cancer undergoing definitive chemoradiotherapy

摘要

摘要:
目的分析外周血中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）在接受根治性放疗的宫颈癌病人预后评估中的意义。
方法回顾性分析125例接受根治性放疗局部晚期宫颈癌病人。NLR和PLR在外照射结束后（内照射前）计算，分析NLR和PLR与病人生存、复发情况的相关性以及与临床因素的相关性。
结果外照射结束后NLR和PLR中位值为2.62、114；选取NLR=2.62和PLR=114分别作为截断值。单因素和多因素分析结果显示，国际妇产科联盟分期、外照射结束后NLR值和PLR值是影响宫颈鳞癌病人总生存时间和无病生存率的独立危险因素（P < 0.01和P < 0.05）。
结论炎症标志NLR和PLR是监测根治性放疗病人的治疗反应和评估预后的良好指标。

Abstract:
ObjectiveTo analyze the prognostic significance of peripheral blood neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in patients with cervical cancer receiving definitive chemoradiotherapy.
MethodsOne hundred and twenty-five patients with locally advanced cervical cancer who received definitive chemoradiotherapy were analyzed retrospectively.NLR and PLR were calculated after external irradiation (before internal irradiation), and the correlation of NLR and PLR with survival, recurrence, and clinical factors were analyzed.
ResultsAfter external irradiation, the median values of NLR and PLR were 2.62 and 114, respectively, and NLR=2.62 and PLR=114 were selected as cut-off values.By means of univariate and multivariate analysis, the results showed that the International Federation of Gynaecology and Obstetrics and Obstetrics staging, NLR, and PLR were independent risk factors for overall survival and disease-free survival in patients with cervical squamous cell carcinoma after external irradiation (P < 0.01 and P < 0.05)
ConclusionsThe inflammatory markers including NLR and PLR can be a new method for monitoring the treatment response and prognosis of definitive chemoradiotherapy patients.

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