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    卢园园, 李浩宇, 耿嘉逸, 雷思思, 刘晨阳, 康品方, 张宁汝. 心房颤动病人IL-1β、Calpain-2水平与心脏结构重构的相关性研究[J]. 蚌埠医科大学学报, 2023, 48(1): 95-99. DOI: 10.13898/j.cnki.issn.1000-2200.2023.01.018
    引用本文: 卢园园, 李浩宇, 耿嘉逸, 雷思思, 刘晨阳, 康品方, 张宁汝. 心房颤动病人IL-1β、Calpain-2水平与心脏结构重构的相关性研究[J]. 蚌埠医科大学学报, 2023, 48(1): 95-99. DOI: 10.13898/j.cnki.issn.1000-2200.2023.01.018
    shu
    LU Yuan-yuan, LI Hao-yu, GENG Jia-yi, LEI Si-si, LIU Chen-yang, KANG Pin-fang, ZHANG Ning-ru. Relationship between IL-1β, Calpain-2 levels and cardiac structure in patients with atrial fibrillation[J]. Journal of Bengbu Medical University, 2023, 48(1): 95-99. DOI: 10.13898/j.cnki.issn.1000-2200.2023.01.018
    Citation: LU Yuan-yuan, LI Hao-yu, GENG Jia-yi, LEI Si-si, LIU Chen-yang, KANG Pin-fang, ZHANG Ning-ru. Relationship between IL-1β, Calpain-2 levels and cardiac structure in patients with atrial fibrillation[J]. Journal of Bengbu Medical University, 2023, 48(1): 95-99. DOI: 10.13898/j.cnki.issn.1000-2200.2023.01.018
    shu

    心房颤动病人IL-1β、Calpain-2水平与心脏结构重构的相关性研究

    Relationship between IL-1β, Calpain-2 levels and cardiac structure in patients with atrial fibrillation

      摘要
    • 摘要:
      目的探讨心房颤动(房颤)病人血清中白细胞介素-1β(IL-1β)、钙蛋白酶-2(Calpain-2)表达水平及与心脏结构重构的相关性。
      方法选取确诊为房颤的病人150例为观察组, 依据2020年ESC/EACTS房颤诊断和管理指南将其分为非阵发性房颤组和阵发性房颤组; 选取同时段健康体检者120名作为对照组。分别检测血清IL-1β、Calpain-2以及超声心动图中左心室舒张期内径(LVDd)、左心房内径(LAD)、左心室射血分数(LVEF)和左心室缩短分数(FS)等指标, 比较3组不同指标是否存在差异; 运用Pearson相关性分析血清IL-1β、Calpain-2与超声心动图检查结果的相关性; 采用二元logistic回归分析, 探寻房颤的危险因素。
      结果观察组中IL-1β、Calpain-2含量显著高于对照组(P < 0.05), 而且非阵发性房颤病人明显高于阵发性房颤病人(P < 0.05)。在超声心动图指标中非阵发性房颤组LAD、LVDd均高于阵发性房颤组以及对照组(P < 0.05), LVEF、FS均低于阵发性房颤组及对照组(P < 0.05)。二元logistic回归分析显示IL-1β、Calpain-2是房颤发生的危险因素。Spearman相关性分析显示IL-1β、Calpain-2与LAD、LVDd呈正相关关系(P < 0.01), 而与LVEF、FS呈显著负相关关系(P < 0.01)。
      结论IL-1β、Calpain-2与LAD、LVDd呈正相关关系, 参与了心脏结构重构过程, 进而促进了房颤的发生与发展。

       

      Abstract:
      ObjectiveTo investigate the relationship between the expression levels of interleukin-1β(IL-1β), calpain-2(Calpain-2) and cardiac remodeling in patients with atrial fibrillation.
      MethodsA total of 150 patients diagnosed with atrial fibrillation(AF) were selected as the observation group, and divided into non-paroxysmal AF group and paroxysmal AF group according to the 2020 ESC/EACTS GUIDELINES for the diagnosis and Management of AF.A total of 120 healthy subjects at the same period were selected as the control group.Serum IL-1β, Calpain-2 contents, left ventricular diastolic diameter(LVDd), left atrial diameter(LAD), left ventricular ejection fraction(LVEF) and left ventricular shortening fraction(FS) were detected by echocardiography, and the differences among the three groups were compared.Pearson correlation was used to analyze the correlation between serum IL-1β and Calpain-2 contents and the results of echocardiography.Binary logistic regression was used to explore the risk factors of AF.
      ResultsThe contents of serum IL-1β and Calpain-2 in the observation group were significantly higher than those in the control group(P < 0.05), and those in the patients without paroxysmal AF were significantly higher than those in the patients with paroxysmal AF(P < 0.05).The indexes of LAD and LVDd in non-paroxysmal AF group were higher than those in paroxysmal AF group and control group(P < 0.05), but LVEF and FS were lower than those in paroxysmal AF group and control group(P < 0.05).Spearman correlation analysis showed that IL-1β and Calpain-2 were positively correlated with LAD and LVDd(P < 0.01), but negatively correlated with LVEF and FS(P < 0.01).Binary logistic regression analysis showed that IL-1β and Calpain-2 were the risk factors for AF.
      ConclusionsIL-1β and Calpain-2 were positively correlated with LAD and LVDd, and were involved in the process of cardiac remodeling, thus promoting the occurrence and development of atrial fibrillation.

       

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