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    刘时华, 张超, 田志刚, 陈雷, 钟平. 缺血性脑白质病变病人血清VEGF表达水平及其临床意义[J]. 蚌埠医科大学学报, 2023, 48(2): 182-185. DOI: 10.13898/j.cnki.issn.1000-2200.2023.02.010
    引用本文: 刘时华, 张超, 田志刚, 陈雷, 钟平. 缺血性脑白质病变病人血清VEGF表达水平及其临床意义[J]. 蚌埠医科大学学报, 2023, 48(2): 182-185. DOI: 10.13898/j.cnki.issn.1000-2200.2023.02.010
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    LIU Shi-hua, ZHANG Chao, TIAN Zhi-gang, CHEN Lei, ZHONG Ping. Expression and clinical significance of serum VEGF in patients with white matter ischemic lesions[J]. Journal of Bengbu Medical University, 2023, 48(2): 182-185. DOI: 10.13898/j.cnki.issn.1000-2200.2023.02.010
    Citation: LIU Shi-hua, ZHANG Chao, TIAN Zhi-gang, CHEN Lei, ZHONG Ping. Expression and clinical significance of serum VEGF in patients with white matter ischemic lesions[J]. Journal of Bengbu Medical University, 2023, 48(2): 182-185. DOI: 10.13898/j.cnki.issn.1000-2200.2023.02.010
    shu

    缺血性脑白质病变病人血清VEGF表达水平及其临床意义

    Expression and clinical significance of serum VEGF in patients with white matter ischemic lesions

      摘要
    • 摘要:
      目的探讨缺血性脑白质病变（white matter ischemic lesions，WMIL）病人血清血管内皮生长因子（vascular endothelial growth factor，VEGF）水平表达及其与WMIL的关系。
      方法选取经颅脑磁共振证实的缺血性脑白质病变病人为研究对象，依据Fazekas评定量表评定脑白质病变程度。选取同期年龄和性别相匹配的颅脑磁共振正常的健康体检者作为对照组。应用酶联免疫吸附法测定病人血清VEGF水平。比较2组的一般临床资料和VEGF水平，采用Pearson相关分析分析血清VEGF水平与脑白质病变程度的关系，采用多因素logistic回归分析分析WMIL的影响因素。
      结果共纳入WMIL组115例，对照组69例。WMIL组病人高血压比例、糖尿病比例和VEGF水平均高于对照组（P < 0.01）。WMIL组病人血清VEGF水平与Fazekas评分呈正相关（r=0.871，P < 0.01）。多因素logistic回归分析显示，高血压、糖尿病和VEGF水平升高是WMIL的独立危险因素（OR＝5.350、3.010、19.382，P < 0.01）。
      结论血清VEGF在WMIL病人中表达水平显著升高，其水平升高是WMIL的独立危险因素，且与WMIL的严重程度呈正相关，血清VEGF水平可作为脑白质慢性损伤的有效的生物学指标之一。

       

      Abstract:
      ObjectiveTo explore the expression level of serum vascular endothelial growth factor(VEGF) in patients with white matter ischemic lesions(WMIL) and its relationship with WMIL.
      MethodsPatients with WMIL confirmed by craniocerebral magnetic resonance were selected as the research subjects, and the degree of white matter lesions was evaluated according to the Fazekas rating scale.Those with normal craniocerebral magnetic resonance matched with age and sex during the same period were selected as the control group.Serum VEGF concentrations were detected with enzyme-linked immunosorbent assay.The general clinical data and VEGF protein levels were compared between the two groups.Pearson correlation analysis was used to analyze the relationship between serum VEGF levels and the degree of white matter lesions, and multivariate logistic regression analysis was used to analyze the influencing factors of WMIL.
      ResultsA total of 115 patients in the WMIL group and 69 in the control group were included in this study.The proportion of hypertension and diabetes mellitus, and the level of VEGF in the WMIL group were significantly higher than those in the control group(P < 0.01).There was a significant positive correlation between serum VEGF level and Fazekas score in the WMIL group(r=0.871, P < 0.01).Multivariate logistic regression analysis showed that hypertension, diabetes mellitus and elevated VEGF levels were independent risk factors for WMIL(OR=5.350, 3.010, 19.382, P < 0.01).
      ConclusionsThe expression level of serum VEGF in WMIL patients is significantly increased.The increased level of serum VEGF may be an independent risk factor for WMIL and is positively correlated with the severity for WMIL.It may be used as one of the effective biological indicators of chronic white matter damage.

       

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