标准四联联合荆花胃康胶丸对Hp阳性慢性萎缩性胃炎病人血清胃泌素17、PG及免疫功能的影响

李艳; 赵婷

doi:10.13898/j.cnki.issn.1000-2200.2023.02.020

标准四联联合荆花胃康胶丸对Hp阳性慢性萎缩性胃炎病人血清胃泌素17、PG及免疫功能的影响

李艳,
赵婷

Effect of standard quadruple combined with Jinghua Weikang capsule on the levels of serum gastrin 17 and PG, and immune function in chronic atrophic gastritis patients with positive Hp

LI Yan,
ZHAO Ting

摘要

摘要:
目的分析标准四联联合荆花胃康胶丸对幽门螺旋杆菌（Hp）阳性慢性萎缩性胃炎病人血清胃泌素17（gastrin 17，G-17）、胃蛋白酶原（pepsinogen，PG）及免疫功能的影响。
方法选择120例Hp阳性慢性萎缩性胃炎病人作为研究对象。按随机数字表法分为2组，其中对照组60例，采用标准四联疗法；观察组60例，在对照组基础上联合荆花胃康胶丸进行治疗。比较2组临床疗效、Hp根除率、治疗前后血清G-17、PGⅠ、PGⅡ、CD4⁺、CD8⁺、CD4⁺/CD8⁺水平及不良反应发生情况。
结果观察组临床总有效率为93.33%，Hp清除率为96.67%，高于对照组的75.00%和81.67%，差异均有统计意义（P < 0.01）；2组治疗后血清G-17、PGⅠ水平均明显上升，PGⅡ水平明显下降，且观察组血清G-17、PGⅠ水平高于对照组，PGⅡ水平低于对照组，差异均有统计意义（P < 0.05~P < 0.01）；2组治疗后CD4⁺和CD4⁺/CD8⁺水平均明显升高，CD8⁺明显降低，且观察组CD4⁺、CD8⁺、CD4⁺/CD8⁺水平明显优于对照组，差异均有统计意义（P < 0.05~P < 0.01）；2组不良反应率差异无统计意义（P>0.05）。
结论标准四联联合荆花胃康胶丸能够有效改善Hp阳性慢性萎缩性胃炎病人血清G-17、PG及免疫功能水平，提高Hp清除率及临床总有效率，值得临床予以推广应用。

Abstract:
ObjectiveTo analyze the effects of standard quadruple combined with Jinghua Weikang capsule on the levels of serum gastrin 17(G-17) and pepsinogen(PG), and immune function in chronic atrophic gastritis patients with positive Hp.
MethodsOne hundred and twenty chronic atrophic gastritis patients with positive Hp were divided into the observation group and control group according to the random number table method(60 cases in each group).The standard quadruple therapy in the control group were given, and the Jinghua Weikang capsule treatment in the observation group were additionally given on the basis of the control group.The clinical efficacy, eradication rate of Hp, serum levels of G-17, PGⅠ, PGⅡ, CD4⁺, CD8⁺, CD4⁺/CD8⁺ before and after treatment, and incidence rate of adverse reactions were compared between two groups.
ResultsThe total clinical effective rate and clearance rate of Hp in the observation group were 93.33% and 96.67%, respectively, which were significantly higher than those in control group(75.00% and 81.67%)(P < 0.01).After treatment, the serum levels of G-17 and PGⅠ significantly increased, while the level of PG Ⅱ significantly decreased in two groups; the serum levels of G-17 and PGⅠ in observation group were significantly higher than those in control group, and the PG Ⅱ level in observation group was significantly lower than that in control group(P < 0.05 to P < 0.01).After treatment, the levels of CD4⁺ and CD4⁺/CD8⁺ significantly increased, and the CD8⁺ level significantly decreased in two groups; the levels of CD4⁺, CD8⁺ and CD4⁺/CD8⁺ in observation group were significantly better than those in control group(P < 0.05 to P < 0.01).There was no statistical significance in the incidence rate of adverse reactions between two groups(P>0.05).
ConclusionsThe standard quadruple combined with Jinghua Weikang capsule can effectively improve the serum levels of G-17, PG and immune function in chronic atrophic gastritis patients with positive Hp, clearance rate of Hp and clinical total effective rate, which is worthy of clinical application.

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