HOXB7和VEGF对肝细胞癌病人预后影响的研究

邢树山; 郭智珍; 叶程远; 郎捷

doi:10.13898/j.cnki.issn.1000-2200.2023.03.017

HOXB7和VEGF对肝细胞癌病人预后影响的研究

Effect of HOXB7 and VEGF on the prognosis of patients with HCC

摘要

摘要:
目的通过研究肝细胞癌病人同源盒基因B7(HOXB7)和血管内皮生长因子(VEGF)的表达，探讨其对肝细胞癌病人术后预后的影响。
方法收集74例肝细胞癌病人临床病理和生存数据，应用免疫组织化学对术后病理标本进行HOXB7和VEGF染色。分析影响病人预后的因素。
结果74例病人术后3年和5年总生存率分别为67.6%和48.6%。多因素分析显示，HOXB7(P < 0.01, HR=1.139)，VEGF(P < 0.01, HR=1.192)、Child-Pugh分级(P < 0.01, HR=4.100)、T分期(P < 0.01, HR=4.317)、肿瘤数量(P < 0.01, HR=2.639)是影响病人生存的独立危险因素。免疫组织化学染色显示，HOXB7和VEGF表达影响病人5年生存率。
结论HOXB7和VEGF过表达影响肝细胞癌病人生存率和预后，是预后不良的因素。

Abstract:
ObjectiveTo investigate the effect of homeobox B7 (HOXB7) and vascular endothelial growth factor(VEGF) expressions on the prognosis of patients with hepatocellular carcinoma(HCC) after operation.
MethodsSeventy-four patients with HCC following surgical resection were enrolled.Clinicopathological and survival data were analyzed, and immunohistochemical staining method for HOXB7 and VEGF expressions measurement was performed on tissue microarray sections.
ResultsThe 3-and 5-year overall survival rates in the 74 patients were 67.6% and 48.6%, respectively.Multivariate analysis revealed that HOXB7(P < 0.01, HR=1.139) and VEGF(P < 0.01, HR=1.192) expressions, Child-Pugh class(P < 0.01, HR=4.100), T stage(P < 0.01, HR=4.317), Tumor number(P < 0.01, HR=2.639) were the independent prognostic factors for overall survival rate.Immunohistochemical staining results showed that the expressions of HOXB7 and VEGF influenced the 5-year survival rate.
ConclusionsHOXB7 and VEGF overexpression affect the survival and prognosis of HCC patients, which suggesting a poor overall survival rate.

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