自然流产女性117例染色体结构稳定性研究

Study on the stability of chromosome structures in 117 women with spontaneous abortion

摘要:
目的观察自然流产女性外周血淋巴细胞姐妹染色单体互换(sister-chromatid exchange, SCE)频率，探讨SCE与自然流产之间的关系。
方法收集自然流产女性117例为观察组，收集同期健康育龄女性50名为对照组，按SCE检测方法检测2组受试者外周血淋巴细胞，计数SCE互换频率。
结果观察组和对照组女性外周血淋巴细胞SCE互换频率分别为(8.04±2.30)次和(6.43±1.50)次，2组差异有统计学意义(P < 0.01)。
结论女性自然流产可能与SCE互换频率异常有关。

Abstract:
ObjectiveTo observe the frequency of sister-chromatid exchange(SCE)in peripheral blood lymphocytes of women with spontaneous abortion, and analyze the relationship between SCE and spontaneous abortion.
MethodsOne hundred and seventeen women with spontaneous abortion and fifty normal reproductive healthy women were divided into the observation group and control group, respectively.The peripheral blood lymphocytes were detected by SCE method to count the frequency of SCE.
ResultsThe SCE frequency in observation group and control group were(8.04±2.30)and(6.43±1.50), respectively.The difference of SCE frequency between two groups was statistically significant(P < 0.01).
ConclusionsThe female spontaneous abortion may be related to the abnormal frequency of SCE.