血清维生素A、E水平与子痫前期发病和病情严重程度的关系

陆燕; 蔡奚梅; 朱丹婴

doi:10.13898/j.cnki.issn.1000-2200.2023.03.020

血清维生素A、E水平与子痫前期发病和病情严重程度的关系

Relationship between the serum vitamin A and E levels, and onset and severity of preeclampsia

摘要

摘要:
目的探讨血清维生素A、E水平与子痫前期发病和病情严重程度的关系。
方法选取诊断为子痫前期的孕妇257例作为研究对象，并根据子痫前期病情严重程度将其分为轻度组104例和重度组153例；另选取同期正常孕妇12 822例纳入对照组。比较3组孕妇血清维生素A、E水平和舒张压(DBP)、收缩压(SBP)、血肌酐(Scr)、24 h尿蛋白定量(24 hpro)；分析维生素A、E与DBP、SBP、SCr、24 hpro的相关性；分析维生素A、E对子痫前期的预测价值。
结果重度组孕妇维生素A、E水平均明显低于轻度组和对照组，轻度组亦明显低于对照组(P < 0.01)；重度组DBP、SBP、Scr、24 hpro均明显低于轻度组和对照组，轻度组亦明显低于对照组(P < 0.01)。Pearson相关分析显示，子痫前期孕妇维生素A、E水平与DBP、SBP、SCr、24 hpro均呈负相关关系(P < 0.05)。以0.35 mg/dL为截断点时，维生素A水平预测子痫前期的灵敏度、特异度分别为63.3%和60.9%(P < 0.05)。以16.85 mg/dL为截断点时，维生素E水平预测子痫前期的灵敏度为72.1%，特异度为69.7%(P < 0.05)。
结论子痫前期孕妇存在血清维生素A、E水平异常，且与病情严重程度具有一定的相关性，可对孕妇血清维生素A、E水平进行监测及控制。

Abstract:
ObjectiveTo investigate the relationship between the serum vitamin A and E levels, and onset and severity of preeclampsia.
MethodsA total of 257 pregnant women with preeclampsia were divided into the mild group(n=104) and severe group(n=153) according to the severity of preeclampsia, and 12 822 normal pregnant women were set as the control group.The serum levels of vitamin A and E, diastolic blood pressure(DBP), systolic blood pressure(SBP), serum creatinine(Scr) and 24-hour urinary protein quantification(24 hpro) were compared among three groups.The correlation of vitamin A and E with DBP, SBP, SCr and 24 hpro were analyzed, and the predictive value of vitamin A and E to preeclampsia was analyzed.
ResultsThe vitamin A and E levels in severe group were significantly lower than those in mild group and control group, and those in mild group were also significantly lower than those in control group(P < 0.01).The DBP, SBP, Scr and 24 hpro in severe group were significantly lower than those in mild group and control group, and those in mild group were significantly lower than those in control group(P < 0.01).The results of Pearson correlation analysis showed that the serum levels of vitamin A and E were negatively correlated with DBP, SBP, SCr, and 24 hpro(P < 0.05).When the cut-off point was 0.35 mg/dL, the sensitivity and specificity of vitamin A to predict the preeclampsia were 63.3% and 60.9%, respectively(P < 0.05).When the cut-off point was 16.85 mg/dL, the sensitivity and specificity of vitamin E to predict the preeclampsia were 72.1% and 69.7%, respectively(P < 0.05).
ConclusionsThe levels of serum vitamin A and E levels are abnormal in pregnant women with preeclampsia, which has a certain correlation with the severity of disease.The levels of serum vitamin A and E should be strictly monitored and controlled.

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