尿四项蛋白和血UA、FT3与高血压早期肾损伤的相关性分析

吴庆四; 袁润林; 蔡欣; 汪霁

doi:10.13898/j.cnki.issn.1000-2200.2023.03.028

尿四项蛋白和血UA、FT3与高血压早期肾损伤的相关性分析

Analysis of correlation between four-item urinary proteins combined with serum UA, FT3 and early kidney injury of hypertension

摘要

摘要:
目的测定高血压早期肾损伤时尿四项蛋白及血各项指标的水平，探讨其与高血压早期肾损伤的相关性，及其在高血压早期肾损伤中的临床应用价值。
方法选取60例高血压病人作为研究对象，按照尿微量白蛋白(mAlb)/尿肌酐(Ucr)比值(albumin/urine creatinine ratio, ACR)分为高血压微量蛋白尿组30例和单纯高血压组30例，同时选取同期健康体检者30名作为对照组，分别检测尿mAlb、β2-微球蛋白(β2-MG)、转铁蛋白(TRF)、免疫球蛋白G(IgG)以及血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、尿酸(UA)、尿素(UREA)、肌酐(Scr)等水平。
结果高血压微量蛋白尿组尿mAlb、β2-MG、TRF、IgG、血UA、UREA、Scr水平均高于对照组和单纯高血压组(P < 0.01)，单纯高血压组尿mAlb、β2-MG、TRF、IgG、血UA、UREA、Scr与对照组差异均无统计学意义(P>0.05)，与对照组相比，单纯高血压组和高血压微量蛋白尿组FT3水平均减少(P < 0.01)。Pearson相关分析显示: 高血压微量蛋白尿组尿mAlb、β2-MG、TRF、IgG、血UA与尿ACR、血UREA、Scr均呈正相关关系(P < 0.05)，FT3与尿ACR、血UREA、Scr均呈负相关关系(P < 0.01)。
结论尿mAlb、β2-MG、TRF、IgG和血UA、FT3对高血压肾损伤的早期诊断有重要指导意义。

Abstract:
ObjectiveTo detect the levels of four-item urinary proteins and blood indexes in patients with early kidney injury of hypertension, and to explore their correlations with early kidney injury of hypertension and its clinical value in the treatment of patients with early kidney injury of hypertension.
MethodsSixty patients with hypertension were selected as the study subjects.They were divided into hypertension microalbuminuria group (n=30) and simple hypertension group (n=30) according to urinary microalbumin (mAlb) to urinary creatinine (Ucr) ratio (ACR).Meanwhile, 30 healthy adults were selected as control group.And the corresponding urinary mAlb, β2-microglobulin (β2-MG), transferrin (TRF), immunoglobulin G (IgG), serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), uric acid (UA), serum urea (UREA) and creatinine (Scr) were detected, respectively.
ResultsThe urinary mAlb, β2-MG, TRF, IgG, serum concentrations of UA, UREA and Scr in the hypertension microalbuminuria group were high than those in both the control group and simple hypertension group (P < 0.01).There was no significant difference in the urinary mAlb, β2-MG, TRF, IgG, serum concentrations of UA, UREA, Scr between the simple hypertension group and the control group (P>0.05).Compared with the control group, the levels of FT3 in both simple hypertension group and hypertension microalbuminuria group were decreased (P < 0.01).Pearson correlation analysis showed that mAlb, β2-MG, TRF, IgG and UA in hypertension microalbuminuria group were positively correlated with ACR, UREA and Scr (P < 0.05), and FT3 was negatively correlated with ACR, UREA and Scr (P < 0.01).
ConclusionsUrinary mAlb, β2-MG, TRF, IgG and serum concentrations of UA, FT3 can serve as effective indexes for the early kidney injury of hypertension.

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