ObjectiveTo investigate the correlation between neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic immune inflammatory index (SII) and the prognosis of newly diagnosed multiple myeloma (MM) patients.

MethodsAfter six months of treatment, the patients with MM for the first time were divided into the remission group (n=34) and non-remission group (n=25) according to their prognosis condition.The relationship among NLR, PLR, SII and the outcome of MM patients was explored, the independent risk factors of MM prognosis were analyzed by logistic regression analysis, and ROC curve was used to evaluate the prognostic value.

ResultsThere were no significant differences in PLR, underlying diseases, age, gender, blood calcium concentration and creatinine between the remission group and the non-remission group (P>0.05).NLR and SII in remission group were lower than those in non-remission group (P < 0.01).Multivariate logistic regression analysis showed that high level of SII was an independent risk factor for MM prognosis (OR=1.005, P < 0.05).ROC curve analysis indicated that the area under the curve was 0.754 and the specificity was 85.3% when SII predicted the survival of patients.The area under the curve of NLR was 0.722 and the specificity was 79.4%.

ConclusionsNLR and SII can be used to evaluate the prognosis of MM.Furthermore, the prognostic value of SII is better than NLR.