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    心房颤动病人血清SLC7A11、FGF23水平检测及临床意义

    Detection and clinical significance of serum SLC7A11 and FGF23 levels in patients with atrial fibrillation

      摘要
    • 摘要:
      目的检测心房颤动(AF)病人与窦性心律者血清溶质载体家族7成员11(SLC7A11)、血清成纤维细胞生长因子23(FGF23)的水平，分析二者与AF之间的相关性及临床意义。
      方法选取住院的AF病人118例作为观察组，根据相关指南分为阵发性AF组67例和非阵发性AF组51例。对照组选取窦性心律健康者96名。选择酶联吸附免疫实验法(ELISA)测出血清中SLC7A11、FGF23浓度；比较3组病人的临床资料及血清学指标，利用Pearson相关性分析血清SLC7A11、FGF23水平与超声心动图中左房内径(LAD)、左室舒张内径(LVD)、左心室射血分数(LVEF)和左心室缩短分数(FS)相关性。采用多元logsitic回归分析AF病人AF发生持续相关因素。
      结果与对照组相比，血清SLC7A11在阵发性AF组和非阵发性AF组均下降(P < 0.01)，且非阵发性AF组中SLC7A11低于阵发性AF组(P < 0.01)，血清FGF23在阵发性AF组和非阵发性AF组均升高(P < 0.01)，且非阵发性AF组中FGF23高于阵发性AF组(P < 0.01)；Pearson相关性分析显示，LAD与血清SLC7A11呈负相关关系(r=-0.534，P < 0.01)，与血清FGF23呈正相关关系(r=0.532，P < 0.01)。多元logsitic回归分析结果显示，SLC7A11是AF独立的保护因素(OR=0.231, P < 0.01)，而FGF23是独立危险因素(OR=1.097, P < 0.01)。
      结论SLC7A11、FGF23可能与AF的发病、进展有关。

       

      Abstract:
      ObjectiveTo detect the levels of serum solute carrier family 7 member 11 (SLC7A11) and serum fibroblast growth factor 23 (FGF23) in patients with atrial fibrillation (AF) and sinus rhythm, and analyze the correlation between them and AF and their clinical significance.
      MethodsA total of 120 AF patients who were hospitalized were selected as observation group. According to relevant guidelines, they were divided into paroxysmal AF group (70 cases) and non-paroxysmal AF group (50 cases). In the control group, 96 healthy patients with sinus rhythm were selected. The concentrations of SLC7A11 and FGF23 in serum were measured by enzyme-linked immunosorbent assay (ELISA). The clinical data and serological indexes of the three groups were compared, and the correlation between serum SLC7A11 and FGF23 levels and left atrial diameter (LAD), left ventricular diastolic diameter (LVD), left ventricular ejection fraction (LVEF) and left ventricular shortening fraction (FS) in echocardiography was analyzed by Pearson correlation analysis. Multivariate logistic regression was used to analyze the factors related to the occurrence and persistence of AF in patients with AF.
      ResultsCompared with control group, serum SLC7A11 was decreased in paroxysmal AF group and in non-paroxysmal AF group (P < 0.01), and SLC7A11 in non-paroxysmal AF group was lower than that of paroxysmal AF group (P < 0.01);serum FGF23 was increased in paroxysmal AF group and in non-paroxysmal AF group (P < 0.01), and FGF23 in non-paroxysmal AF group was higher than that of paroxysmal AF group (P < 0.01). Pearson correlation analysis showed that LAD was negatively correlated with serum SLC7A11 (r=0.534, P < 0.01), and positively correlated with serum FGF23 (r=0.532, P < 0.01). Multiple logistic regression analysis results showed that SLC7A11 was an independent protective factor for AF (OR=0.231, P < 0.01), while FGF23 was an independent risk factor (OR=1.097, P < 0.01).
      ConclusionsSLC7A11 and FGF23 may be associated with the occurence and progression of AF.

       

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