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    胡树凤, 程方兵, 王嘉伟, 马斌. 高血压病人血清锌指蛋白A20、p53表达及与冠状动脉病变的关系[J]. 蚌埠医科大学学报, 2023, 48(5): 614-617. DOI: 10.13898/j.cnki.issn.1000-2200.2023.05.014
    引用本文: 胡树凤, 程方兵, 王嘉伟, 马斌. 高血压病人血清锌指蛋白A20、p53表达及与冠状动脉病变的关系[J]. 蚌埠医科大学学报, 2023, 48(5): 614-617. DOI: 10.13898/j.cnki.issn.1000-2200.2023.05.014
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    HU Shu-feng, CHENG Fang-bing, WANG Jia-wei, MA Bin. Expression of serum zinc finger protein A20 and p53 in patients with hypertension and their relationship with coronary artery disease[J]. Journal of Bengbu Medical University, 2023, 48(5): 614-617. DOI: 10.13898/j.cnki.issn.1000-2200.2023.05.014
    Citation: HU Shu-feng, CHENG Fang-bing, WANG Jia-wei, MA Bin. Expression of serum zinc finger protein A20 and p53 in patients with hypertension and their relationship with coronary artery disease[J]. Journal of Bengbu Medical University, 2023, 48(5): 614-617. DOI: 10.13898/j.cnki.issn.1000-2200.2023.05.014
    shu

    高血压病人血清锌指蛋白A20、p53表达及与冠状动脉病变的关系

    Expression of serum zinc finger protein A20 and p53 in patients with hypertension and their relationship with coronary artery disease

      摘要
    • 摘要:
      目的分析高血压病人血清锌指蛋白A20、p53表达及与冠状动脉病变的关系。
      方法选取住院行冠状动脉造影检查的高血压病人120例，根据冠状动脉造影结果分为冠状动脉病变组(病变组)70例和冠状动脉正常组(正常组)50例。根据Gensini评分，将病变组病人分为轻度组40例、中度组20例和重度组10例。采用酶联免疫吸附法检测各组血清p53表达水平，实时荧光定量PCR法检测血清锌指蛋白A20 mRNA表达，并分析二者相关性。采用ROC曲线分析血清锌指蛋白A20 mRNA、p53表达水平对高血压病人发生冠状动脉病变的诊断效能。
      结果病变组病人血清A20 mRNA、p53表达和低密度脂蛋白胆固醇水平均明显高于正常组(P < 0.01)。病变组中，重度组病人A20 mRNA明显高于轻度组和中度组，中度组亦明显高于轻度组(P < 0.01)；重度组病人p53高于轻度组(P < 0.05)。病变组血清A20 mRNA表达与p53表达水平呈正相关关系(r＝0.702，P < 0.05)。ROC曲线分析结果显示，血清A20 mRNA、p53表达水平联合诊断高血压病人发生冠状动脉病变的曲线下面积为0.799，敏感度76.80%，特异度为78.40%。
      结论高血压合并冠状动脉病变病人血清锌指蛋白A20 mRNA、p53表达水平随冠状动脉病变的加重有逐渐升高趋势，且二者呈正相关关系，对诊断高血压病人发生冠状动脉病变具有一定临床价值。

       

      Abstract:
      ObjectiveTo analyze the expression of serum zinc finger protein A20 and p53 in patients with hypertension and their relationship with coronary artery disease.
      MethodsOne hundred and twenty patients with hypertension who were hospitalized and underwent coronary angiography were selected.According to the results of coronary angiography, they were divided into coronary artery disease group (disease group, 70 cases) and normal coronary artery group (normal group, 50 cases).According to the Gensini score, patients in the disease group were divided into mild group (40 cases), moderate group (20 cases) and severe group (10 cases).Enzyme-linked immunosorbent assay method was used to detect serum p53 level, real-time fluorescent quantitative PCR method was used to detect serum zinc finger protein A20 mRNA level, and the correlation between the two was analyzed.ROC curve was used to analyze the diagnostic efficacy of serum zinc finger protein A20 mRNA and p53 levels for coronary artery disease in patients with hypertension.
      ResultsCompared with the normal group, the serum zinc finger protein A20 mRNA, p53 and low-density lipoprotein cholesterol levels in the disease group were significantly increased (P < 0.01).The levels of serum zinc finger protein A20 mRNA and p53 in patients with severe coronary artery disease were significantly higher than those in the mild group and moderate group, and the moderate group were higher than the mild group, the difference was statistically significant (P < 0.05 to P < 0.01).The level of serum zinc finger protein A20 mRNA in patients with coronary artery disease was positively correlated with the level of p53 (r=0.702, P < 0.05).ROC curve analysis results showed that the area under the curve of combined diagnosis for coronary artery disease in hypertensive patients was 0.799, with a sensitivity of 76.80%, and a specificity of 78.40%.
      ConclusionsSerum zinc finger protein A20 mRNA and p53 levels in patients with hypertension and coronary artery disease gradually increase with the severity of coronary artery disease, and there is a positive correlation between the two, which has certain value in the diagnosis of coronary artery disease in hypertensive patients.

       

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