碱提酸沉法提取补骨脂中补骨脂乙素的工艺研究

孙小龙; 戴轶群; 马慧; 俞俊霞; 李红梅; 朱美林; 吴成柱

doi:10.13898/j.cnki.issn.1000-2200.2023.05.024

碱提酸沉法提取补骨脂中补骨脂乙素的工艺研究

Study on the extraction process of isobavachalcone from Psoraleae corylifolia using alkaline extraction and acid precipitation

摘要

摘要:
目的通过碱提酸沉的方法对补骨脂乙素的提取进行工艺优化。
方法以补骨脂乙素的含量为指标，通过单因素试验和正交试验考察料液比、碱液浓度、碱提时间、酸沉pH、酸沉时间以及超声时间对补骨脂乙素提取工艺的影响。
结果碱提酸沉法提取补骨脂乙素的最佳工艺为: 料液比为1∶ 10、碱液浓度为4%、碱提时间为2 h、酸沉pH为6、酸沉时间为0.5 h、超声时间为20 min。
结论本研究优化的最佳工艺条件具有良好的复重性，且稳定可靠、经济环保，适合大量提取补骨脂中的补骨脂乙素。

Abstract:
ObjectiveTo optimize the extraction process of isobavachalcone by alkaline extraction and acid precipitation.
MethodsThe content of isobavachalcone was set as the objective parameter.The effects of solid-liquid ratio, alkali concentration, alkali extraction time, acid precipitation pH, acid precipitation time and ultrasound time on extraction process of isobavachalcone were investigated through single factor test and orthogonal test.
ResultsThe optimal extraction conditions of isobavachalcone by alkaline extraction and acid precipitation were as follows: the ratio of solid-liquid for 1∶ 10, alkali concentration for 4 %, alkali extraction time for 2 h, acid precipitation pH 6, acid precipitation time for 0.5 h and ultrasound time for 20 min.
ConclusionsIn this study, the optimal process conditions have the good repeatability, and it is stable, reliable, economical and environmental-friendly, which can greatly improve the extraction rate of isobavachalcone from Psoralea corylifolia.

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