ObjectiveTo explore the effect of sequential enteral nutrition combined with probiotics in the treatment of severe craniocerebral injury.

MethodsTotal 120 patients with severe craniocerebral injury admitted to our hospital were randomly divided into control group(60 cases) and observation group(60 cases) according to the systematic sampling method.The patients in the control group were treated with sequential enteral nutrition support, while the patients in the observation group were treated with probiotics on the basis of sequential enteral nutrition support.After 2 weeks of intervention, the nutritional status, gastrointestinal function, neurological recovery and gastrointestinal complications of the two groups were compared.

ResultsAfter intervention, the levels of serum total hemoglobin, albumin, transferrin and prealbumin in the observation group were significantly higher than those in the control group(P <0.01).The scores of sequential organ failure assessment, acute physiology and chronic health evaluation were significantly lower than those in the control group, and the scores of Glasgow Coma Score were significantly higher than that in the control group(P <0.01).The standard time of enteral nutrition, the first defecation time and the hospital stay in the observation group were significantly shorter than those in the control group(P <0.01).Hair coloring rate, pulmonary infection rate, urinary tract infection rate and gastric retention rate in observation group were lower than those in control group(P <0.05 to P <0.01).

ConclusionsUsing sequential enteral nutrition support combined with probiotics to treat severe craniocerebral injury patients can significantly improve the nutritional status of patients, improve gastrointestinal function, improve the level of gastrointestinal motility, reduce the occurrence of gastrointestinal complications, improve the treatment effect and promote the prognosis, which is worthy of clinical application.