ObjectiveTo investigate the characteristics and risk factors of nosocomial infection in patients with liver failure treated with artificial liver, so as to provide basis for the formulation of intervention measures.

MethodsClinical data and laboratory test results of 207 patients with liver failure were retrospectively collected.The incidence of nosocomial infection in patients with liver failure treated with artificial liver was counted, and the risk factors were analyzed by univariate and binary logistic regression analylsis.

ResultsAmong 207 patients with liver failure treated with artificial liver, 46 patients had nosocomial infection, and the infection rate was 22.22%.Respiratory tract infections 14.01%(29/207) was predominant, followed by spontaneous peritonitis 4.83% (10/207) and bloodstream infections 1.93% (4/207).A total of 48 pathogens were isolated from various specimens of 46 patients, including 12 strains (25.00%) of Gram-positive bacteria, 27 strains (56.25%) of Gram-negative bacteria, and 9 strains (18.75%) of fungi.Multivariate logistic regression analysis showed that advanced age (age ≥60 years) (OR=1.050, 95%CI: 1.014-1.087, P < 0.01), diabetes mellitus (OR=2.597, 95%CI: 1.171-5.763, P < 0.05), catheter indwelling time (OR=1.456, 95%CI: 1.104-1.919, P < 0.01), plasma albumin concentration (OR=0.871, 95%CI: 0.802-0.945, P < 0.01) and MELD score (OR=1.156, 95%CI: 1.058- 1.262, P < 0.01) were independent risk factors for nosocomial infection in patients with liver failure treated with artificial liver.

ConclusionsThe incidence of nosocomial infection in patients with liver failure treated with artificial liver is high.In the process of clinical treatment and nursing, attention should be paid to risk factors, and effective preventive measures should be taken to reduce the occurrence of nosocomial infection.