血清miR-21-3p检测联合淋巴结粗针穿刺活检对甲状腺癌颈淋巴结转移的诊断价值

项柱; 周理好; 曹志国; 陈霖霖; 陈本鑫

doi:10.13898/j.cnki.issn.1000-2200.2023.07.012

血清miR-21-3p检测联合淋巴结粗针穿刺活检对甲状腺癌颈淋巴结转移的诊断价值

Diagnostic value of serum miR-21-3p detection combined with lymph core needle biopsy in cervical lymph node metastasis of thyroid cancer

摘要

摘要:
目的探讨血清miR-21-3p检测联合超声引导下淋巴结粗针穿刺活检(LCNB)对甲状腺癌颈淋巴结转移的诊断价值。
方法选取甲状腺癌伴颈淋巴结肿大(均行血清miR-21-3p检测及LCNB)病人80例，以手术病理为标准，比较血清miR-21-3p检测、超声引导下LCNB及两者联合检查对甲状腺癌伴颈淋巴结转移的诊断价值。
结果80例病人经手术病理检查，有淋巴结转移者49例，无转移者31例。血清miR-21-3p检测联合超声引导下LCNB诊断甲状腺癌伴颈淋巴结转移准确度为91.8%、灵敏度为87.6%，均高于两者独立检查准确度76.2%、84.7%和灵敏度82.3%、85.7%(P < 0.05)，联合检查受试者工作曲线下面积为0.907 1，大于两者单独检测的0.776 5、0.829 2(P < 0.05)。
结论相较于单独检测，血清miR-21-3p联合超声引导下LCNB诊断甲状腺癌淋巴结转移的准确度、灵敏度更好，诊断效能更高。

Abstract:
ObjectiveTo investigate the value of serum miR-21-3p detection combined with ultrasound-guided lymph core needle biopsy (LCNB) in the diagnosis of cervical lymph node metastasis of thyroid cancer.
MethodsA total of 80 patients with thyroid cancer with cervical lymph node enlargement received serum miR-21-3p detection and LCNB were collected.The histopathologic results were taken as the gold standard to compare the diagnostic value of serum miR-21-3p, ultrasound-guided LCNB and their combination in thyroid cancer with cervical lymph node metastasis.
ResultsThe histopathologic results showed cervical lymph node metastasis in 49 patients and no cervical lymph node metastasis in 31 patients.The accuracy and sensitivity of serum miR-21-3p detection combined with ultrasound-guided LCNB in the diagnosis of thyroid cancer with cervical lymph node metastasis were 91.8% and 87.6%, respectively, which were higher than the accuracy of 76.2%, 84.7% and sensitivity of 82.3% and 85.7% of the two independent examinations (P < 0.05).The area under the receiver operator characteristic curve of the combined examination was 0.907 1, which was higher than that of the two independent examinations (0.776 5 and 0.829 2) (P < 0.05).
ConclusionsCompared with single detection, serum miR-21-3p combined with ultrasound-guided LCNB has better accuracy, sensitivity and diagnostic efficiency in the diagnosis of lymph node metastasis of thyroid cancer.

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