胆囊结石合并非酒精性脂肪肝病与代谢综合征的关系研究

徐春林; 李敏; 曹葆强; 龚仁华

doi:10.13898/j.cnki.issn.1000-2200.2023.07.017

胆囊结石合并非酒精性脂肪肝病与代谢综合征的关系研究

Relationship between cholecystolithiasis complicated with non-alcoholic fatty liver disease and metabolic syndrome

摘要

摘要:
目的探讨胆囊结石合并非酒精性脂肪肝病(NAFLD)与代谢综合征(MS)的关系。
方法按照性别、年龄匹配原则，1:1比例选择60例胆囊结石合并NAFLD病人纳入观察组(因1例病人主动退出，实际纳入59例)，60例胆囊结石未合并NAFLD病人纳入对照组进行病例对照研究。收集2组病人一般资料、代谢综合征(MS)相关指标，包括：腰围、体质量指数(BMI)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗(IR)、谷氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)等指标并进行差异性分析。采用多因素条件logistic回归分析筛选危险因素。
结果观察组病人MS患病率高于对照组(P < 0.05)。观察组病人腰围与对照组比较差异有统计学意义(P < 0.05)。观察组病人BMI、MS、TG、TC、ALT、FINS、IR、TNF-α、IL-6水平均高于对照组(P < 0.05)。多因素条件logistic回归分析显示，BMI、TG、ALT、IR、TNF-α、IL-6是胆囊结石合并NAFLD的独立危险因素(P < 0.05)。
结论BMI、TG、ALT、IR、TNF-α、IL-6是胆囊结石合并NAFLD的独立危险因素；胆囊结石合并NAFLD与MS密切相关。

Abstract:
ObjectiveTo explore the relationship between cholecystolithiasis complicated with non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS).
MethodsAccording to the principle of sex and age match, we conducted a case-control study with 60 patients with cholecystolithiasis complicated with NAFLD in observation group (1 patient withdrew voluntarily, 59 patients were actually included) and 60 patients with cholecystolithiasis in control group.The general data and related indexes of MS were collected, including waistline, body mass index(BMI), triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-C), fasting blood glucose (FPG), fasting insulin (FINS), insulin resistance (IR), alanine aminotransferase (ALT), alanine aminotransferase (AST), tumour necrosis factor-α(TNF-α), interleukin-6 (IL-6), etc.The differences between two groups were analyzed and multivariate conditions logistic regression analysis was used to screen risk factors.
ResultsThe prevalence of MS in the observation group was higher than that in the control group (P < 0.05).There was significant difference in waist circumference between the observation group and the control group (P < 0.05).The levels of BMI, MS, TG, TC, ALT, FINS, IR, TNF-α and IL-6 in the observation group were significantly higher than those in the control groups (P < 0.05).Multivariate condition logistic regression analysis showed that BMI, TG, ALT, IR, TNF-α, IL-6 were independent risk factors for cholecystolithiasis complicated with NAFLD (P < 0.05).
ConclusionsBMI, TG, ALT, IR, TNF-α, IL-6 are independent risk factors for cholecystolithiasis complicated with NAFLD.Cholecystolithiasis with NAFLD complicated is closely associated with MS.

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