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    穴位贴敷联合补肾活血法对复发性流产病人外周血中抗β2糖蛋白Ⅰ抗体、血小板功能的有效性分析

    Effectiveness analysis of acupoint application combined with kidney tonification and blood activation method on anti-β2 glycoprotein Ⅰ antibody and platelet function in patients with recurrent abortion

      摘要
    • 摘要:
      目的探究穴位贴敷联合补肾活血法对复发性流产病人的有效性分析。
      方法选取复发性流产病人90例，将其随机分为西药组(A组)、西药+中药组(B组)、西药+中医综合治疗组(C组)，每组30例。A组：口服阿司匹林；B组：口服阿司匹林同时给予补肾活血中药；C组在B组的基础上应用穴位贴敷；均至孕12周。观察3组病人治疗前后临床疗效、血清人绒毛促性腺激素(hCG)、孕酮(P)、抗心磷脂抗体(ACA)、抗β2糖蛋白Ⅰ抗体(Anti-β2-GPⅠ)及B超情况等。
      结果治疗后，3组疗效差异有统计学意义(P < 0.05)；C组疗效高于A、B组(P < 0.05~P < 0.01)。治疗后，3组病人hCG与P较同组治疗前明显升高(P < 0.01)，C组明显高于A、B组(P < 0.01)。治疗后，B、C组病人ACA及Anti-β2-GPI阳性率均较同组治疗前降低(P < 0.05)，A组与治疗前比较降低程度差异无统计学意义(P>0.05)。治疗后，3组ACA和Anti-β2-GPI阳性率比较，差异均有统计学意义(P>0.05)，其中C组低于A组和B组(P < 0.05)。治疗后，3组血小板功能均有所改善，D-二聚体(D-D)水平明显低于治疗前(P < 0.01)，C组D-D水平明显低于A、B组(P < 0.01)，B组明显低于A组(P < 0.01)。
      结论穴位贴敷联合补肾活血法对复发性流产病人治疗具有显著疗效，可有效改善病人激素水平及血小板功能，提高病人治愈率，值得在临床应用。

       

      Abstract:
      ObjectiveTo investigate the effectiveness analysis of acupoint application combined with kidney tonification and blood activation method on patients with recurrent abortion.
      MethodsA total of 90 patients with recurrent abortion were selected and randomly divided into western medicine group (group A), western medicine + triditional Chinese medicine group (group B) and western medicine + Chinese medicine comprehensive treatment group (group C), with 30 patients in each group.Group A: oral aspirin; group B: oral aspirin and triditional Chinese medicine for kidney tonification and blood activation; group C: acupoint application on the basis of group B; all until 12 weeks of pregnancy.The clinical efficacy, serum human chorionic gonadotropin (hCG), progesterone (P), anti-cardiolipin antibody (ACA), anti-β2-glycoprotein Ⅰ antibody (anti-β2-GPⅠ) and ultrasound were observed before and after treatment in the three groups.
      ResultsAfter treatment, the differences were statistically significant in the efficacy of the three groups (P < 0.05), and the efficacy of group C was higher than that of group A and group B (P < 0.05 to P < 0.01).The hCG and P were significantly higher in patients of the three groups compared with the same group before treatment (P < 0.01), and group C was significantly higher than group A and group B (P < 0.01).The positive rates of ACA and anti-β2-GPⅠ in group B and group C were lower than those before treatment in the same group (P < 0.05), and the difference between the degree of reduction in group A and before treatment was not statistically significant (P>0.05).The positive rates of ACA and anti-β2-GPⅠ between the three groups were statistically significant (P>0.05), among which, group C was lower than group A and group B (P < 0.05).The platelet function improved in all groups, the (D-D) levels were significantly lower than before treatment (P < 0.01), the D-D levels in group C were significantly lower than those in group A and group B (P < 0.01), and group B was significantly lower than group A (P < 0.01).
      ConclusionsAcupoint application combined with kidney tonification and blood activation method has significant efficacy in the treatment of patients with recurrent abortion, which can effectively improve the hormone level and platelet function of patients and increase the cure rate of patients, and is worthy of clinical application.

       

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