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    乳腺MRI征象及半定量增强对三阴性乳腺癌的诊断价值

    Diagnostic value of MRI features and semiquantitative kinetic analysis in triple negative breast cancer

      摘要
    • 摘要:
      目的探讨三阴性乳腺癌(triple negative breast cancer, TNBC)的动态增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging, DCE-MRI)征象和半定量参数的特点。
      方法回顾性分析经手术病理证实的三阴性乳腺癌(TNBC)病人30例, 非三阴性乳腺癌(nTNBC)病人60例作为对照组。比较2组MRI征象(病灶最大直径、ADC值、病灶形态、边缘、数量、瘤内T2WI信号强度及瘤周水肿)和半定量参数峰值时间(Tpeak)、早期信号强化率(SER)、最大强化率(Epeak)之间的差异。
      结果相较于nTNBC组, TNBC组病灶多表现为瘤内T2WI高信号、瘤周水肿、增强早期环形强化(P < 0.05~P < 0.01), 而2组病灶最大直径、ADC值、病灶形态、边缘、数量差异均无统计学意义(P>0.05)。与nTNBC组相比, TNBC组的Tpeak值较小(P < 0.01), Epeak值和SER值较高(P < 0.05和P < 0.01)。
      结论三阴性乳腺癌DCE-MRI表现有一定的特征性, 早期环形强化、瘤周水肿、瘤内T2WI高信号、较快的Tpeak、较高的SER和Epeak值是诊断TNBC的重要征象。

       

      Abstract:
      ObjectiveTo investigate the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) features and corresponding semiquantitative parameters in triple negative breast cancer (TNBC).
      MethodsA total of 30 patients with surgical-pathologically confirmed TNBC and 60 patients with surgical-pathologically confirmed non-TNBC (nTNBC) were analyzed retrospectively.The MRI features (maximum diameter of lesion, ADC value, mass shape, margins, tumor number, intratumoral signal intensity in T2WI, peritumoral edema) and the semiquantitative parameters (Tpeak, SER, Epeak) were compared between the two groups.
      ResultsCompared with the nTNBC group, the TNBC group showed high intratumoral T2WI signal, peritumoral edema, and enhanced early ring enhancement (P < 0.05 to P < 0.01), while there were no significant differences in the maximum diameter, ADC value, mass shape, tumor margin and tumor number between the two groups (P>0.05).Compared with the nTNBC group, the TNBC group showed lower Tpeak (P < 0.01), higher SER values and Epeak values (P < 0.05 and P < 0.01).
      ConclusionsDCE-MRI manifestation of TNBC has some characteristics, including early rim enhancement, peritumoral edema, high signal intensity on T2WI, fast Tpeak, high SER and Epeak, which can be served as important features in diagnosis.

       

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