ObjectiveTo explore the clinical significance of the coagulation function index levels in patients with active multiple sclerosis(MS).

MethodsForty-four patients with active MS and 88 healthy people were divided into the MS group and control group, respectively.The 5 mL of fasting venous blood in two groups were collected.The levels of fibrinogen, D-dimer, activated partial thromboplastin time, plasma prothrombin time and thrombin time were compared between two groups.The correlation between the EDSS score and levels of fibrinogen, D-dimer, activated partial thromboplastin time, plasma prothrombin time, thrombin time, serum alanine aminotransferase, aspartate aminotransferase, platelets and creatinine were analyzed using Spearman correlation analysis.The multiple regression analysis was used to further prove the correlation between the EDSS score and above blood indicators.The ROC curve was used to evaluate the sensitivity and specificity of fibrinogen and activated partial thromboplastin time to active MS.

ResultsThe levels of plasma fibrinogen and D-dimer in MS group were higher than those in control group(P < 0.01).The activated partial thromboplastin time in MS group was lower than that in control group(P < 0.01).The fibrinogen level was positively correlated with EDSS score(B=0.623, P < 0.05), and the activated partial thromboplastin time level was negatively correlated with EDSS score(B=-0.187, P < 0.05).The sensitivity and specificity of the fibrinogen and activated partial thromboplastin time in predicting the activity of MS were 47.73% & 70.45% and 60.47% & 80.68%, respectively.

ConclusionsIncreased fibrinogen and shortened activated partial thrombin time may be the risk factors of the severity of MS.The coagulation function indicators in patients with MS should be regularly tested, and patients with high levels of fibrinogen, D-dimer and activated partial thromboplastin time should be vigilant against MS activity.