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    2型糖尿病病人中25羟维生素D与甲状腺功能及甲状腺自身抗体的相关性研究

    Relationship between 25-hydroxyvitamin D and thyroid function and thyroid autoantibodies in patients with type 2 diabetes mellitus

      摘要
    • 摘要:
      目的探讨2型糖尿病病人中血清25羟维生素D(25-OH-VD)水平与甲状腺功能及甲状腺自身抗体之间的关系。
      方法选取2型糖尿病病人181例，其中维生素D缺乏组101例，维生素D不足组62例，维生素D充足组18例。分析3组中25-OH-VD水平与总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、抗甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)以及空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血脂等指标的相关性。
      结果维生素D缺乏组与维生素D充足组的甲状腺功能水平差异均无统计学意义(P>0.05)，但维生素D缺乏组TgAb、TPOAb、胆固醇(TC)、三酰甘油(TG)、HbA1c高于维生素D充足组(P < 0.05)。相关性分析显示25-OH-VD与HbA1c、TT3、TgAb、TPOAb、TG、TC、性别均呈负相关(P < 0.05)。logistic回归结果发现，性别及25-OH-VD是TPOAb阳性的影响因素。
      结论维生素D缺乏在2型糖尿病中很常见，维生素D的缺乏程度与HbA1c水平相关，且高25-OH-VD水平是TPOAb阳性的保护因素。

       

      Abstract:
      ObjectiveTo investigate the relationship between serum 25-hydroxyvitamin D (25-OH-VD) level and thyroid function and thyroid autoantibodies in patients with type 2 diabetes mellitus.
      MethodsA total of 181 patients with type 2 diabetes mellitus were selected, including 101 patients with vitamin D deficiency, 62 patients with vitamin D insufficiency, and 18 patients with vitamin D sufficiency.The correlations between 25-OH-VD and total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), anti-thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb), fasting blood glucose, glycosylated hemoglobin (HbA1c) and blood lipids among the three groups were analyzed.
      ResultsThere was no significant difference in thyroid function between the vitamin D deficient group and the vitamin D sufficient group (P>0.05), but the levels of TgAb, TPOAb, Cholesterol (TC), triglyceride (TG) and HbA1c in the vitamin D deficient group were higher than those in the vitamin D sufficient group (P < 0.05).Correlation analysis showed that 25-OH-VD was negatively correlated with HbA1c, TT3, TgAb, TPOAb, TG, TC and sex (P < 0.05).Logistic regression results found that sex and 25-OH-VD were the influencing factor of TPOAb positivity.
      ConclusionsVitamin D deficiency is common in type 2 diabetes mellitus.The level of vitamin D deficiency is correlated with the level of HbA1c, moreover, high 25-OH-VD level is a protective factor for TPOAb positivity.

       

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