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    李桂茹, 袁玉敏, 岳冬梅. 室性心律失常病人血清GDF-15、NT-proBNP、CD40L水平变化与预后的关系[J]. 蚌埠医科大学学报, 2023, 48(12): 1680-1684. DOI: 10.13898/j.cnki.issn.1000-2200.2023.12.013
    引用本文: 李桂茹, 袁玉敏, 岳冬梅. 室性心律失常病人血清GDF-15、NT-proBNP、CD40L水平变化与预后的关系[J]. 蚌埠医科大学学报, 2023, 48(12): 1680-1684. DOI: 10.13898/j.cnki.issn.1000-2200.2023.12.013
    shu
    LI Gui-ru, YUAN Yu-min, YUE Dong-mei. Relationship between changes of serum GDF-15, NT-proBNP, CD40L levels and prognosis in patients with ventricular arrhythmia[J]. Journal of Bengbu Medical University, 2023, 48(12): 1680-1684. DOI: 10.13898/j.cnki.issn.1000-2200.2023.12.013
    Citation: LI Gui-ru, YUAN Yu-min, YUE Dong-mei. Relationship between changes of serum GDF-15, NT-proBNP, CD40L levels and prognosis in patients with ventricular arrhythmia[J]. Journal of Bengbu Medical University, 2023, 48(12): 1680-1684. DOI: 10.13898/j.cnki.issn.1000-2200.2023.12.013
    shu

    室性心律失常病人血清GDF-15、NT-proBNP、CD40L水平变化与预后的关系

    Relationship between changes of serum GDF-15, NT-proBNP, CD40L levels and prognosis in patients with ventricular arrhythmia

      摘要
    • 摘要:
      目的探究室性心律失常病人血清生长分化因子-15（GDF-15）、N末端-B型利钠肽原（NT-proBNP）、白细胞分化抗原40配体（CD40L）水平变化与预后的关系。
      方法选取180例室性心律失常病人作为观察组，另选取同期健康体检者60名作为对照组。比较2组血清GDF-15、NT-proBNP、CD40L水平，分析血清GDF-15、NT-proBNP、CD40L水平与Lown分级的相关性，比较不同预后病人血清GDF-15、NT-proBNP、CD40L水平，分析血清GDF-15、NT-proBNP、CD40L水平与室性心律失常病人预后的关系，绘制受试者工作（ROC）曲线，评价血清GDF-15、NT-proBNP、CD40L水平对室性心律失常病人预后的预测价值。
      结果观察组血清GDF-15、NT-proBNP、CD40L水平明显高于对照组（P<0.01）；Spearman相关性可知，室性心律失常病人血清GDF-15、NT-proBNP、CD40L水平与Lown分级呈正相关关系（P<0.05）；预后不良病人血清GDF-15水平、NT-proBNP、CD40L均明显高于预后良好病人（P<0.01）；logistic回归分析结果显示，血清GDF-15、NT-proBNP、CD40L水平均为室性心律失常病人预后影响因素（P<0.01），且血清GDF-15、NT-proBNP、CD40L水平对室性心律失常病人预后的预测价值的AUC分别为0.666、0.767、0.777，各指标联合的AUC为0.855。
      结论室性心律失常病人血清GDF-15、NT-proBNP、CD40L水平明显升高，临床监测其水平，有助于预测预后，指导临床治疗方案制定。

       

      Abstract:
      ObjectiveTo investigate the relationship between changes of serum growth differentiation factor-15 (GDF-15), N-terminal-B-type natriuretic peptide (NT-proBNP), leukocyte differentiation antigen 40 ligand (CD40L) levels and prognosis in patients with ventricular arrhythmia.
      MethodsA total of 180 patients with ventricular arrhythmia were selected as the observation group, and 60 healthy individuals who underwent physical examinations during the same period were selected as the control group.The serum GDF-15, NT-proBNP, CD40L levels were compared between the two groups.The correlation between serum GDF-15, NT-proBNP, CD40L levels and Lown grading were analyzed.The serum GDF-15, NT-proBNP, CD40L levels in patients with different prognosis were compared.The relationship between serum GDF-15, NT-proBNP, CD40L levels and the prognosis of patients with ventricular arrhythmia were analyzed.Receiver operating characteristic (ROC) curve was drawn, and the predictive value of serum GDF-15, NT-proBNP, and CD40L levels in the prognosis of patients with ventricular arrhythmia were evaluated.
      ResultsThe serum GDF-15, NT-proBNP and CD40L levels of the observation group were significantly higher than those of the control group (P<0.01).Spearman correlation indicated that there was a positive correlation between serum levels of GDF-15, NT-proBNP, and CD40L in patients with ventricular arrhythmia and Lown grading (P<0.05).The serum GDF-15, NT-proBNP, and CD40L levels in patients with poor prognosis were significantly higher than those of patients with good prognosis (P<0.01).Logistic regression analysis showed that serum levels of GDF-15, NT-proBNP, and CD40L were all influencing factors for the prognosis of patients with ventricular arrhythmia (P<0.05), and the AUC of the predictive value of serum GDF-15, NT-proBNP, and CD40L levels for the prognosis of patients with ventricular arrhythmia were 0.666, 0.767, and 0.777, respectively, and the AUC of all indicators in combination was 0.855.
      ConclusionsThe serum levels of GDF-15, NT-proBNP and CD40L in patients with ventricular arrhythmia are significantly increased.Clinical monitoring of their levels can help predict the prognosis and guide the formulation of clinical treatment plans.

       

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