ObjectiveTo explore the effects of aspirin combined with clopidogrel, aspirin combined with agatroban on ischemic modified albumin (IMA) and neural function in patients with transient ischemic attack.

MethodsA total of 124 patients with transient ischemic attack were divided into two groups according to the random number table method.The control group (62 cases) was treated with aspirin and clopidogrel, and the observation group (62 cases) was treated with aspirin and agatroban.After 14 days of treatment, the scores of IMA, National Institute of Health stroke scale (NIHSS) score, fibrinogen (FIB), activated partial thrombin time (APTT), prothrombin time (PT), matrix metalloproteinase 9 (MMP-9) and disease remission rate were compared between the two groups.

ResultsThere was no statistical difference in MMP-9, FIB, PT, APTT and NIHSS scores in each time period between the two groups (P>0.05).The IMA in the observation group was higher than that in the control group 14 days after treatment (P < 0.05).At the same time, the disease remission rates in the observation group were higher than those in the control group 7 days, 10 days and 14 days after treatment (P < 0.05).

ConclusionsAspirin combined with clopidogrel and aspirin combined with agatroban can reduce neural impairment, improve IMA and blood coagulation function, but for patients with transient ischemic attack, aspirin combined with agatroban is more effective.