系统性红斑狼疮病人衰弱现状及其影响因素分析

张雨歌; 洪静芳; 张海玲; 张敏

doi:10.13898/j.cnki.issn.1000-2200.2023.12.026

系统性红斑狼疮病人衰弱现状及其影响因素分析

Status and influencing factors of frailty in patients with systemic lupus erythematosus

摘要

摘要:
目的探究系统性红斑狼疮（SLE）病人衰弱现状并分析其影响因素。
方法运用便利抽样法选取203例SLE病人作为研究对象。应用一般资料调查表、中文版Tilburg衰弱量表、Charlson合并症指数（Charlson comorbidity index，CCI）及Barthel评定量表对研究对象进行调查。
结果SLE病人衰弱得分7（7，10）分，衰弱的发生率为73.9%。合并症指数评分在2分以上的占56.2%。Barthel评定量表得分（90.05±15.64）分。Spearman相关分析结果表明，衰弱和多重用药（r_s=0.215）、CCI（r_s=0.485）呈正相关关系（P < 0.05），与自理能力呈负相关关系（r_s=-0.538，P < 0.01）。多元线性回归分析结果显示，年龄增大、CCI得分高、BI得分低、多重用药等可能是系统性红斑狼疮病人衰弱得分高的独立危险因素（P < 0.05~P < 0.01）。
结论SLE病人的衰弱发生率较高，医务人员应早期识别病人衰弱并制定和实施个性化的干预措施，降低衰弱的发生率。

Abstract:
ObjectiveTo explore the frailty status of patients with systemic lupus erythematosus (SLE) and analyze its influencing factors.
MethodsA convenience sampling method was performed to select 203 patients with SLE as the research subjects.The general data questionnaire, Chinese version of Tilburg frailty scale, Charlson comorbidity index (CCI) and Barthel index were used to investigate the research subjects.
ResultsThe frailty score of patients with SLE was 7 (7, 10) points, the morbidity of frailty was 73.9%.The Charlson comorbidity index score was above 2 points in 56.2%.The Barthel index score was (90.05±15.64) points.Spearman correlation analysis showed that the frailty was positively correlated with polypharmacy (r_s=0.215), CCI (r_s=0.485) (P < 0.05), and negatively correlated with self-care ability (r_s=-0.538, P < 0.01).The results of the multiple linear regression analysis showed that increased age, high CCI scores, low BI scores and polypharmacy might be independent risk factors for high frailty scores in patients with SLE (P < 0.05 to P < 0.01).
ConclusionsThe incidence of frailty in SLE patients is high.Medical staff should identify frailty early, formulate and implement individualized intervention measures to reduce its incidence.

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