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    杨梦, 任帅, 袁永丰, 李源, 赵雅桐, 陈建方, 王中秋. 2型糖尿病人群与正常人群胸腰椎骨密度的差异分析[J]. 蚌埠医科大学学报, 2024, 49(1): 32-35. DOI: 10.13898/j.cnki.issn.1000-2200.2024.01.007
    引用本文: 杨梦, 任帅, 袁永丰, 李源, 赵雅桐, 陈建方, 王中秋. 2型糖尿病人群与正常人群胸腰椎骨密度的差异分析[J]. 蚌埠医科大学学报, 2024, 49(1): 32-35. DOI: 10.13898/j.cnki.issn.1000-2200.2024.01.007
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    YANG Meng, REN Shuai, YUAN Yongfeng, LI Yuan, ZHAO Yatong, CHEN Jianfang, WANG Zhongqiu. Analysis of the difference of thoracolumbar vertebral bone mineral density between type 2 diabetes mellitus population and normal population[J]. Journal of Bengbu Medical University, 2024, 49(1): 32-35. DOI: 10.13898/j.cnki.issn.1000-2200.2024.01.007
    Citation: YANG Meng, REN Shuai, YUAN Yongfeng, LI Yuan, ZHAO Yatong, CHEN Jianfang, WANG Zhongqiu. Analysis of the difference of thoracolumbar vertebral bone mineral density between type 2 diabetes mellitus population and normal population[J]. Journal of Bengbu Medical University, 2024, 49(1): 32-35. DOI: 10.13898/j.cnki.issn.1000-2200.2024.01.007
    shu

    2型糖尿病人群与正常人群胸腰椎骨密度的差异分析

    Analysis of the difference of thoracolumbar vertebral bone mineral density between type 2 diabetes mellitus population and normal population

      摘要
    • 摘要:
      目的探讨2型糖尿病（T2DM）病人与正常人群间的胸腰椎椎体骨密度（BMD）的分布差异。
      方法选取T2DM病人68例作为观察组，选取同期健康体检者96名作为对照组。基于定量CT测量T11~L4椎体的BMD。2组再根据体质量指数（BMI）、年龄和性别分为不同亚组，比较2组一般资料、不同年龄分组胸腰椎骨质疏松症（OP）发生率、不同BMI分组胸腰椎BMD和不同性别分组胸腰椎BMD。
      结果观察组病人BMI和空腹血糖均高于对照组（P < 0.05和P < 0.01）；2组受试者胸腰椎BMD均呈逐渐下降的趋势，观察组从T11~L4椎体的BMD均低于对照组（P < 0.05~P < 0.01）。随着年龄增加，2组T11~L2椎体发生OP的概率增加（P < 0.01）。当BMI < 24 kg/m2，观察组胸腰椎BMD均低于对照组（P < 0.05）。在女性组，观察组胸腰椎BMD均低于对照组（P < 0.05~P < 0.01）；在男性组，2组胸腰椎BMD差异均无统计学意义（P>0.05）。
      结论随着年龄的增加，T2DM病人和健康人群胸腰椎BMD均降低，BMD降低与性别和BMI有关；T2DM病人更易发生OP。因此，T2DM病人应加强椎体BMD的相关检查，尽早采取措施缓解骨量减少及预防OP的发生。

       

      Abstract:
      ObjectiveTo investigate the distribution difference of thoracolumbar vertebral bone mineral density (BMD) between type 2 diabetes mellitus (T2DM) patients and normal population.
      MethodsSixty-eight T2DM patients were selected as the observation group, and 96 health examinees at the same period were selected as the control group.BMD of T11-L4 vertebral body was measured based on quantitative CT.The two groups were divided into different subgroups according to body mass index (BMI), age and sex.The general data of the two groups, incidence of thoracolumbar vertebral osteoporosis (OP) in different age groups, thoracolumbar vertebral BMD in different BMI groups and thoracolumbar vertebral BMD in different sex groups were compared.
      ResultsThe BMI and fasting blood glucose of patients in the observation group were higher than those in the control group (P < 0.05 and P < 0.01).The thoracolumbar vertebral BMD of the subjects in the two groups showed a gradual downward trend, and the BMD of the T11-L4 vertebrae in the observation group was lower than that in the control group (P < 0.05 to P < 0.01).With the increase of age, the incidence of OP in T11-L2 vertebrae in the two groups increased (P < 0.01).When BMI < 24 kg/m2, the thoracolumbar vertebral BMD in the observation group was lower than that in the control group (P < 0.05).In the female group, the thoracolumbar vertebral BMD in the observation group was lower than that in the control group (P < 0.05 to P < 0.01);in the male group, there was no significant difference in thoracolumbar vertebral BMD between the two groups (P>0.05).
      ConclusionsWith the increase of age, thoracolumbar vertebral BMD decreases in both T2DM patients and normal population, which is related to sex and BMI, and T2DM patients are more likely to suffer OP.Therefore, T2DM patients should strengthen the relevant examination of vertebral BMD, and take measures to alleviate bone loss and prevent the occurrence of OP as soon as possible.

       

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