miRNA-16、circRNA-100679、miRNA-124表达水平与抑郁症严重程度的相关性研究

徐彩霞; 蒋庆

doi:10.13898/j.cnki.issn.1000-2200.2024.01.019

miRNA-16、circRNA-100679、miRNA-124表达水平与抑郁症严重程度的相关性研究

徐彩霞,
蒋庆

Correlation between the expression levels of miRNA-16, circRNA-100679 and miRNA-124 and severity of depression

摘要

摘要:
目的了解微小RNA（miRNA）-16、环形RNA（circRNA）-100679、miRNA-124表达水平与抑郁症严重程度的相关性。
方法将首次确诊为抑郁症的81例病人定义为观察组，将同期体检且结果提示无明显异常的80名健康成年人定义为对照组。比较2组miRNA-16、circRNA-100679、miRNA-124的RNA相对表达量，根据汉密尔顿抑郁量表17版本（HAMD-17）评分变化将观察组病人分为A、B、C 3组，比较其RNA相对表达量，并进行相关分析。
结果治疗后，观察组miRNA-16、circRNA-100679相对表达量较治疗前升高，miRNA-124相对表达量较治疗前降低（P＜0.01），与对照组比较差异有统计学意义（P＜0.05）。治疗后，A、B、C 3组HAMD-17评分下降，miRNA-16、circRNA-100679相对表达量较治疗前升高，miRNA-124相对表达量较治疗前降低（P＜0.01），HAMD-17评分、miRNA-124相对表达量情况，A组＜B组＜C组（P＜0.01），miRNA-16、circRNA-100679相对表达量情况，A组>B组>C组（P＜0.01）。miRNA-124相对表达量与HAMD-17评分呈正相关关系（r=0.557，P＜0.05），miRNA-16、circRNA-100679相对表达量与HAMD-17评分呈负相关关系（r=-0.325，P＜0.01；r=-0.453，P＜0.05）。
结论miRNA-16、circRNA-100679、miRNA-124相对表达量均与抑郁症严重程度具有相关性，调控其表达水平可能为抑郁症的治疗提供新的思路。

Abstract:
ObjectiveTo know the correlation between the expression levels of microRNA(miRNA)-16, circular RNA(circRNA)-100679 and miRNA-124, and severity of depression.
MethodsEighty-one patients diagnosed with depression for the first time and 80 healthy adults at the same time were divided into the observation group and control group, respectively.The relative RNA expression levels of miRNA-16, circRNA-100679 and miRNA-124 were compared between two groups.According to the changes of Hamilton depression scale version 17(HAMD-17), the observation group was subdivided into the A, B and C groups, the relative expression of RNA among three groups was compared, and the correlation of which was analyzed.
ResultsAfter treatment, the relative expression levels of miRNA-16 and circRNA-100679 in the observation group increased compared with those before treatment, while the relative expression levels of miRNA-124 in the observation group decreased compared with that before treatment(P < 0.01), and the differences of which between two groups were statistically significant(P < 0.05).After treatment, the HAMD-17 scores in A, B and C groups decreased, the relative expression levels of miRNA-16 and circRNA-100679 increased, and the relative expression of miRNA-124 decreased compared with those before treatment(P < 0.01).The HAMD-17 scores and relative expression level of miRNA-124 in group A, group B and group C gradually increased in turn(P < 0.01), and the relative expression levels of miRNA-16 and circRNA-100679 in group A, group B and group C gradually decreased in turn(P < 0.01).The relative expression levels of miRNA-124 were positively correlated with the HAMD-17 score(r=0.557, P < 0.05), and the relative expression levels of miRNA-16 and circRNA-100679 were negatively correlated with the HAMD-17 score(r=-0.325, P < 0.01;r=0.453, P < 0.05).
ConclusionsThe relative expression levels of miRNA-16, circRNA-100679 and miRNA-124 are correlated with the severity of depression.Regulating its expression level may provide a new idea for the treatment of depression.

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