Abstract: Objective: To investigate the status of depression and anxiety in patients with breast cancer and analyze its influencing factors.Methods: A total of 289 patients with breast cancer were selected.A self-designed general questionnaire, including age, marital status, education level, chemotherapy reaction severity, immunohistochemical classification and other general data, was used to collect the general information.Zung self-rating depression scale(SDS) and self-rating anxiety scale(SAS) were then performed to investigate the status of depression and anxiety among the patients.The data were obtained and compared with the data under the Chinese normal model, and the influencing factors were analyzed.Results: Among the 289 patients, there were 68 cases of depression and 44 cases of anxiety, with the incidence of depression and anxiety being 23.53% and 15.22%, respectively.The scores of both SDS and SAS in patients with breast cancer were significantly higher than those in Chinese normal model(P<0.01).Further analysis revealed that neoadjuvant chemotherapy status, chemotherapy reaction severity, education level and temperament type were the influencing factors of depression in breast cancer patients(P<0.05 to P<0.01);and axillary lymph node dissection status, neoadjuvant chemotherapy status and chemotherapy reaction severity were the influencing factors of anxiety in breast cancer patients(P<0.05 to P<0.01).Moreover, the incidence of depression was found less frequently in the patients with sanguineous temperament, which accounted for 12.50%(8/64);and more frequently in the patients with depression temperament, which accounted for 35.00%(14/40).Conclusions: Female patients with breast cancer often have negative emotions of anxiety and depression in clinical observation.Intervention against the factors causing relevant negative emotions may play a role in the management of breast cancer patients.