原发性干燥综合征继发免疫性血小板减少症的临床特点及危险因素分析

王丽丽; 黄鸿影; 王信; 赵韵琦; 陈琳洁

doi:10.13898/j.cnki.issn.1000-2200.2024.02.006

原发性干燥综合征继发免疫性血小板减少症的临床特点及危险因素分析

Analysis of clinical characteristics and risk factors in primary Sjögren's syndrome with secondary immune thrombocytopenia

摘要

摘要:
目的了解原发性干燥综合征(pSS)相关继发免疫性血小板减少症(ITP)的发生率和临床特点。
方法回顾性收集498例pSS病人的临床资料及实验室检查结果，比较pSS继发ITP病人(观察组)和血小板计数正常病人(对照组)间临床表现、实验室检查及免疫学指标特征。
结果498例pSS病人中，有17.86%(89/498)病人继发ITP。与对照组比较，观察组病人表现出更高的疾病活动度、更低的补体C3水平(P < 0.01)。此外，pSS继发ITP病人较少发生关节炎(15.8% vs 5.6%，P < 0.05)及间质性肺病(16.5% vs 4.5%，P < 0.05)。
结论继发性ITP是pSS病人常见并发症。其主要临床特点有更低的补体C3水平及更高的疾病活动度评分，而间质性肺病和关节炎的发生是继发ITP的独立保护因素。

Abstract:
ObjectiveTo evaluate the incidence and clinical characteristics in primary Sjögren's syndrome(pSS) with secondary immune thrombocytopenia (ITP).
MethodsFour hundred and ninety-eight pSS patients were retrospectively analyzed.Clinical manifestations, laboratory results and immunological index characteristics were compared between pSS patients with or without ITP.
ResultsAmong the 498 pSS patients, 17.86%(89/498) had the secondary ITP, and the ITP group showed the higher disease activity and lower C3 levels(P < 0.01) compared with the control group (P < 0.01).In addition, pSS patients with secondary ITP had less arthritis(15.8% vs 5.6%, P < 0.05) and interstitial lung disease(16.5% vs 4.5%, P < 0.05).
ConclusionsSecondary ITP is a common complication in patients with pSS.The main clinical characteristics include the decreased complement C3 levels and higher disease activity score.However, the development of interstitial lung diseases and arthritis were independent protective factors for secondary ITP in pSS patients.

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