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    富血小板纤维蛋白联合Bio-Oss骨粉修复颌骨囊肿术后骨缺损的疗效

    Effects of platelet-rich fibrin combined with Bio-Oss bone substitute in the repair of postoperative bone defect of jaw cyst

      摘要
    • 摘要:
      目的观察使用富血小板纤维蛋白(platelet-rich fibrin, PRF)联合Bio-Oss骨粉修复颌骨囊肿术后骨缺损的临床疗效。
      方法选取颌骨囊肿术后存在一定大小范围的骨缺损病人共36例作为研究对象，随机分为2组，各18例。对照组病人单纯使用Bio-Oss充填修复骨缺损；观察组病人使用PRF联合Bio-Oss充填颌骨囊肿造成的骨缺损空腔。所有病人术后分别于3、6、12个月进行定期随访观察，通过CBCT影像学检查测量骨密度值评估临床疗效。
      结果观察组颌骨囊肿术后伤口愈合良好，对照组有1例术后7 d创口出现轻度糜烂红肿，未见充填材料排异反应。影像学检查显示观察组较对照组病人颌骨缺损空腔内的充填材料随着时间推移与新生骨及周围骨组织生长良好，能够达到临床满意的骨组织修复效果。观察组术后3、6、12个月骨缺损区骨密度均高于对照组，差异均有统计学意义(P < 0.05~P < 0.01)。
      结论PRF联合Bio-Oss骨粉可有效提高颌骨囊肿术后骨缺损的成骨疗效。

       

      Abstract:
      ObjectiveTo observe the clinical efficacy of platelet-rich fibrin(PRF) combined with Bio-Oss bone substitute in the repair of postoperative bone defect of jaw cyst.
      MethodsA total of 36 patients with bone defects in a certain range after maxillary cyst surgery were randomly divided into the control group and observation group(18 cases in each group).The control group was treated with Bio-Oss filling to repair bone defects, and the observation group was treated with PRF combined with Bio-Oss filling to repair the cavity of bone defect caused by jaw cyst.All patients were regularly followed up for 3, 6 and 12 months after surgery, and the CBCT imaging was used to measure bone mineral density to evaluate the clinical efficacy.
      ResultsThe wounds of jawbone cyst in the observation group healed well after surgery, 1 case with mild erosion and redness in the control group was identified after 7 days of surgery, and no rejection reaction of filling material was be observed.The results of imaging examination showed that compared with the control group, the filling materials in the cavity of jaw defect in the observation group grew well with the new bone and surrounding bone tissue over time, and the bone tissue repair effect could achieve clinical satisfactory.The bone mineral density in observation group was higher than that in control group at 3, 6 and 12 months after surgery(P < 0.05 to P < 0.01).
      ConclusionsThe PRF combined with Bio-Oss bone substitute can effectively promote the osteogenic effect of bone defect after maxillary cyst surgery.

       

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