ObjectiveTo observe the clinical efficacy of platelet-rich fibrin(PRF) combined with Bio-Oss bone substitute in the repair of postoperative bone defect of jaw cyst.

MethodsA total of 36 patients with bone defects in a certain range after maxillary cyst surgery were randomly divided into the control group and observation group(18 cases in each group).The control group was treated with Bio-Oss filling to repair bone defects, and the observation group was treated with PRF combined with Bio-Oss filling to repair the cavity of bone defect caused by jaw cyst.All patients were regularly followed up for 3, 6 and 12 months after surgery, and the CBCT imaging was used to measure bone mineral density to evaluate the clinical efficacy.

ResultsThe wounds of jawbone cyst in the observation group healed well after surgery, 1 case with mild erosion and redness in the control group was identified after 7 days of surgery, and no rejection reaction of filling material was be observed.The results of imaging examination showed that compared with the control group, the filling materials in the cavity of jaw defect in the observation group grew well with the new bone and surrounding bone tissue over time, and the bone tissue repair effect could achieve clinical satisfactory.The bone mineral density in observation group was higher than that in control group at 3, 6 and 12 months after surgery(P < 0.05 to P < 0.01).

ConclusionsThe PRF combined with Bio-Oss bone substitute can effectively promote the osteogenic effect of bone defect after maxillary cyst surgery.