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    高分辨率磁共振参数联合血清MMP9、hs-CRP检测预测大脑中动脉粥样硬化性狭窄病人发生急性卒中的价值

    Value of high-resolution magnetic resonance imaging parameters with serum MMP9 and hs-CRP to predict the occurrence of acute stroke in patients with middle cerebral artery atherosclerotic stenosis

      摘要
    • 摘要:
      目的分析高分辨率磁共振(HRMRI)参数检测联合血清MMP9、hs-CRP指标对大脑中动脉粥样硬化性狭窄病人急性卒中发生的预测价值。
      方法选取183例大脑中动脉粥样硬化性狭窄病人，根据住院期间是否发生急性卒中将其分为急性卒中组89例和无急性卒中组94例。分析狭窄程度及血清MMP9、hs-CRP水平预测大脑中动脉粥样硬化性狭窄病人急性卒中的价值。
      结果急性卒中组易损斑块、狭窄程度、Essen卒中风险评分(ESRS)、血清MMP9、hs-CRP水平均高于无急性卒中组(P < 0.05)；狭窄程度及血清MMP9、hs-CRP水平预测大脑中动脉粥样硬化性狭窄病人发生急性卒中的AUC分别为0.886、0.857、0.634；三者联合预测的AUC为0.923。
      结论血清MMP9、hs-CRP联合HRMRI参数检测可提高了评估急性卒中预测的准确性。

       

      Abstract:
      ObjectiveTo detect the expression levels of serum matrix metalloproteinase-9 (MMP9) and high-sensitivity C reactive protein (hs-CRP) in patients with middle cerebral artery atherosclerotic stenosis and analyze the value of MMP9 and hs-CRP combined with high-resolution magnetic resonance imaging (HRMRI) parameters in predicting the occurrence of acute stroke.
      MethodsA total of 183 patients with middle cerebral artery atherosclerotic stenosis were selected and divided into the acute stroke group (89 cases) and non-acute stroke group (94 cases) according to whether acute stroke occurred during hospitalization.Predictive values of stenosis degree, serum MMP9 and hs-CRP levels in patients with middle cerebral artery atherosclerotic stenosis were analyzed.
      ResultsVulnerable plaque, degree of stenosis, Essen stroke risk score (ESRS) and levels of MMP9, hs-CRP in the acute stroke group were higher than those in non-acute stroke group (P < 0.05).The area under curve (AUC) of degree of stenosis and the levels of MMP9 and hs-CRP in the predictive of acute stroke in patients with atherosclerotic stenosis were 0.886, 0.857 and 0.634, respectively, and AUC of their combination was 0.923.
      ConclusionsSerum MMP9 and hs-CRP combined with HRMRI parameters can greatly improve the accuracy of prediction in acute stroke.

       

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