ObjectiveTo investigate the predictive value of interleukin-10 (IL-10) and catalase (CAT) in post-stroke depression (PSD) in patients with acute ischemic stroke.

MethodsSerum IL-10 and CAT levels in 151 patients with acute ischemic stroke within 24 h of hospital admission were measured.Depressive symptoms were assessed using the 17-item Hamilton depression scale (HAMD-17), and PSD was defined as a HAMD score ≥8.

ResultsAt 1-month follow-up after stroke, 51 (33.8%) patients were diagnosed with PSD.Compared with non-PSD patients, the PSD group had higher NIHSS scores at admission and discharge, larger cerebral infarction volume, lower BI score, higher mRS score, and lower serum CAT and IL-10 levels (P < 0.05).After adjusting for potential confounders (P < 0.05 in univariate logistic regression analysis), IL-10 (OR=0.615, 95%CI: 0.410-0.923) and CAT (OR=0.757, 95%CI: 0.652-0.914) were independent predictors of PSD.IL-10 levels (r=0.394, P < 0.01) and CAT levels (r=0.306, P < 0.01) were negatively correlated with HAMD scores in PSD patients.ROC analysis showed that the cutoff point for serum IL-10 levels was 2.06 pg/mL, and the AUC for predicting PSD was 0.739.Meanwhile, the cutoff point for the CAT level was 1.07 U/L, and the AUC for predicting PSD was 0.630.Patients with lower IL-10 levels (< 2.06 pg/mL) were more likely to develop PSD than their counterparts (≥2.06 pg/mL) (OR=9.750, 95%CI=2.671-35.534, P < 0.01).Meanwhile, patients with lower CAT levels (< 1.07 U/L) were more likely to develop PSD than their counterparts (≥1.07 U/L) (OR=5.052, 95%CI=1.256-20.322, P < 0.05).

ConclusionsSerum IL-10 and CAT can be used as independent protective predictors of PSD in patients with acute ischemic stroke.Patients with low levels of IL-10 and CAT are more likely to develop PSD 1 month after stroke.