血清Kisspeptin、Betatrophin水平与妊娠期糖尿病病人胰岛素抵抗的相关性分析

张艳明; 赵晔; 胡月玲; 史慧芳

doi:10.13898/j.cnki.issn.1000-2200.2024.02.020

血清Kisspeptin、Betatrophin水平与妊娠期糖尿病病人胰岛素抵抗的相关性分析

Correlation between serum Kisspeptin, Betatrophin levels and insulin resistance in gestational diabetes mellitus patients

摘要

摘要:
目的探讨血清人吻素-1(Kisspeptin)、促代谢因子(Betatrophin)水平与妊娠期糖尿病(GDM)病人胰岛素抵抗的相关性。
方法选择86例GDM病人(GDM组)和60例正常妊娠孕妇(NGT组)，均检测血清Kisspeptin、Betatrophin水平，分析其与GDM发生胰岛素抵抗的相关性。
结果GDM组空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、糖化血红蛋白(HbAlc)、总胆固醇(TC)、三酰甘油(TG)、Kisspeptin、Betatrophin水平高于NGT组(P < 0.01)，Pearson相关性分析血清Kisspeptin、Betatrophin水平与TC、TG、PFG、FINS、HOMA-IR呈正相关关系(r=0.367~0.576，P < 0.01)，Kisspeptin与Betatrophin之间呈正相关关系(r=0.326，P < 0.05)。多重线性回归分析Kisspeptin(B=0.671)、Betatrophin(B=0.886)均与GDM病人HOMA-IR独立相关(P < 0.05~P < 0.01)。
结论GDM病人血清Kisspeptin、Betatrophin水平明显升高，Kisspeptin、Betatrophin水平均与GDM病人胰岛素抵抗存在正线性相关关系。

Abstract:
ObjectiveTo investigate the correlation between serum Kisspeptin, Betatrophin levels, insulin resistance in patients with gestational diabetes mellitus (GDM).
MethodsA total of 86 GDM patients (GDM group) and 60 normal pregnant women (NGT group) were selected.Serum Kisspeptin and Betatrophin levels were detected.The correlation between serum Kisspeptin, Betatrophin levels and insulin resistance in GDM was analyzed.
ResultsThe levels of fasting plasma glucose (FPG), fasting insulin (FINS), homeostasis model assessment-insulin resistance (HOMA-IR), hemoglobin A1c (HbA1c), total cholesterol (TC), triglycerides (TG), Kisspeptin and Betatrophin in the GDM group were higher than those in the NGT group (P < 0.01).Pearson correlation analysis showed that serum Kisspeptin and Betatrophin levels were positively correlated with TC, TG, PFG, FINS and HOMA-IR (r=0.367-0.576, P < 0.01), and Kisspeptin was positively correlated with Betatrophin (r=0.326, P < 0.05).Multiple linear regression analysis results showed that Kisspeptin (B=0.671) and Betatrophin (B=0.886) were independently correlated with HOMA-IR in patients with GDM (P < 0.05 to P < 0.01).
ConclusionsSerum Kisspeptin and Betatrophin levels are significantly increased in GDM patients, and there is a positive linear correlation between Kisspeptin, Betatrophin levels and insulin resistance in GDM patients.

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