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    分娩期抗生素预防性治疗对生殖道B族链球菌定植病人妊娠结局及阴道菌群微生态的影响

    Impacts of intrapartum antibiotic prophylaxis during childbirth on pregnancy outcomes and vaginal flora microecology in patients with genital tract group B streptococcus colonization

      摘要
    • 摘要:
      目的 分析分娩期抗生素预防性治疗对生殖道B族链球菌(GBS)定植孕妇妊娠结局及阴道菌群微生态的影响。
      方法 选择产检且分娩的孕妇160例为研究对象，GBS检查均为阳性，依随机分组法分为对照组和观察组，每组80例。对观察组分娩前至少4 h给予抗生素预防治疗，对照组分娩前给予甲硝唑栓治疗，并记录观察组和对照组母婴结局以及阴道菌群微生态情况。
      结果 观察组不良结局总发生率低于对照组(P < 0.05)。治疗后观察组GBS、白细胞酯酶、唾液酸酶、乙酰氨基葡萄糖苷酶、过氧化氢酶检出率较对照组低，阴道菌群密集Ⅱ~Ⅲ度、乳杆菌和清洁度Ⅰ~Ⅱ级检出率较对照组高(P < 0.05~P < 0.01)。观察组孕妇的治疗总有效率为98.75%，高于对照组总有效率83.75%(P < 0.01)。
      结论 分娩期抗生素预防性治疗对GBS定植孕妇妊娠结局有良好的改善作用，可以改善阴道菌群微生态环境。

       

      Abstract:
      Objective To analyze the impacts of intrapartum antibiotic prophylaxis during childbirth on pregnancy outcomes and vaginal flora microecology in patients with genital tract group B Streptococcus (GBS) colonization.
      Methods A total of 160 pregnant women for obstetric examination and gave birth were set as the study subjects.All of them had positive GBS examinations.The patients were randomly divided into control group and observation group, 80 cases in each group.Administer antibiotic prophylactic treatment at least 4 hours before delivery in the observation group, the control group was treated with metronidazole suppository before delivery, and the maternal and infant outcomes and vaginal flora microecology in the observation group and the control group were recorded.
      Results The total incidence of adverse outcomes in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05).After treatment, the detection rates of GBS, leukocyte esterase, sialidase, acetylglucosaminidase and catalase in the observation group were lower than those in the control group, the detection rates of vaginal flora density Ⅱ-Ⅲ, lactobacillus and cleanliness Ⅰ-Ⅱ was higher than that of the control group (P < 0.05 to P < 0.01).The total effective rate of patients in the observation group was 98.75%, which was higher than that in the control group, which was 83.75%(P < 0.01).
      Conclusions Intrapartum antibiotic prophylaxis during childbirth has a good effect on improving pregnancy outcomes in patients with GBS colonization, and can alleviate the microecological environment of vaginal flora, which is worthy of popularization and application in clinical treatment.

       

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