高级检索

    单发甲状腺微小乳头状癌颈部淋巴结转移的危险因素分析

    Analysis of risk factors for cervical lymph node metastasis in single papillary thyroid microcarcinoma

      摘要
    • 摘要:
      目的 探讨影响单发甲状腺微小乳头状癌(PTMC)颈部淋巴结转移的危险因素。
      方法 回顾性分析经手术和病理证实的单发PTMC病人癌结节的超声特征和颈部淋巴结转移的关系，并分析PTMC颈部淋巴结转移的危险因素。
      结果 119例PTMC病人中，无颈部淋巴结转移者86例(72.3%)，颈部淋巴结转移者33例(27.7%)。观察组男性比例高于对照组(P＜0.05)，年龄明显低于对照组(P＜0.01)。PTMC结节的超声特征中，2组癌结节最大径、血流丰富、突破包膜差异均有统计学意义(P＜0.01)。logistic回归分析显示，年龄、癌结节最大径、突破包膜是PTMC颈部淋巴结转移的危险因素(P＜0.01)。ROC曲线分析显示，年龄预测PTMC颈部淋巴结转移的诊断截点为43.5岁，AUC为0.769(95%CI：0.669~0.869)，敏感度为66.7%，特异度为80.2%；癌结节最大径预测PTMC颈部淋巴结转移的诊断截点为6.5 mm，AUC为0.801(95%CI：0.719~0.882)，敏感度为81.8%，特异度为66.3%。
      结论 PTMC病人的年龄、部分超声特征和颈部淋巴结转移存在一定相关性，对PTMC的临床治疗有一定参考作用。

       

      Abstract:
      Objective To investigate the risk factors of cervical lymph node metastasis in single papillary thyroid microcarcinoma (PTMC).
      Methods The relationship between ultrasound features of cancer nodule and cervical lymph node metastasis in patients with single PTMC confirmed by surgery and pathology was analyzed retrospectively, and the risk factors for cervical lymph node metastasis in PTMC were analyzed.
      Results Among the 119 PTMC patients, 86 cases (72.3%) had no cervical lymph node metastasis, and 33 cases (27.7%) had cervical lymph node metastasis. The proportion of males in the observation group was higher than that in the control group (P<0.05), and the age in the observation group was significantly lower than that in the control group (P<0.01). In the ultrasound features of PTMC nodules, there were statistically significant differences in the maximum diameter of cancer nodule, abundant blood flow, and breakthrough of capsule between the two groups (P<0.01). Logistic regression analysis showed that age, maximum diameter of cancer nodule, and breakthrough of capsule were risk factors for cervical lymph node metastasis in PTMC (P<0.01). ROC curve analysis showed that the diagnostic cut-off value of age for predicting cervical lymph node metastasis in PTMC was 43.5 years old, the area under the ROC curve was 0.769 (95%CI: 0.669-0.869), the sensitivity was 66.7%, and the specificity was 80.2%;the diagnostic cut-off value of maximum diameter of cancer nodule for predicting cervical lymph node metastasis in PTMC was 6.5 mm, the area under the ROC curve was 0.801 (95%CI: 0.719-0.882), the sensitivity was 81.8%, and the specificity was 66.3%.
      Conclusions There is a certain correlation between the age, some ultrasound features and cervical lymph node metastasis in PTMC patients, which may provide some references for the clinical treatment of PTMC.

       

      • HTML全文
      • 参考文献(18)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回