Abstract:
Objective To analyze the correlations between the serum levels of anti-Sa and anti-CCP antibody and osteoarticular injury and systemic inflammatory response in patients with rheumatoid arthritis(RA).
Methods One hundred and eight RA patients with osteoarticular injury were divided into the high anti-SA group, low anti-SA group, high anti-CCP group and low anti-CCP group according to the serum levels of anti-Sa and anti-CCP. The differences of WOMAC osteoarthritis index, lysholms knee function score, serum levels of interleukin(IL)-1β, IL-6, IL-27 and tumor necrosis factor α(TNF-α) were compared among all groups. The Pearson test was used to evaluate the correlation of relevant indicators.
Results The WOMAC osteoarthritis indexes in high anti-Sa group and high anti-CCP group were significantly higher than that in low anti-Sa group(P < 0.01), and the lysholms knee function scores in high anti-Sa group and high anti-CCP group were significantly lower than that in low anti-Sa group(P < 0.01). The serum levels of IL-1β, IL-6, IL-27 and TNF-α in the high anti-Sa group and high anti-CCP group were significantly higher than those in low anti-CCP group(P < 0.01). The serum anti-Sa and anti-CCP antibody levels in RA patients were positively correlated with the severity of osteoarticular injury and systemic inflammatory response (P < 0.05 to P < 0.01), and negatively correlated with the lysholms knee function score(P < 0.01).
Conclusions The serum levels of anti-Sa and anti-CCP antibodies in patients with RA significantly increase, which is correlated with the joint injury and systemic inflammatory response, and can be used as a reference index in the clinical judgment of disease activity and osteoarticular injury.
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