孕前体质量指数与妊娠期高血压疾病的相关性研究

    Correlation between pre-pregnancy body mass index and hypertensive disorders of pregnancy in term pregnant women

    • 摘要:
      目的 调查孕妇孕前体质量分布情况,分析孕前体质量指数(BMI)与妊娠期高血压疾病的相关性。
      方法 收集2 618例单胎孕妇的临床资料,根据孕前BMI分为低体质量组234例、正常体质量组1 610例、超重组545例、Ⅰ度肥胖组128例、Ⅱ度肥胖组101例。比较5组孕妇的一般资料和孕产情况,并分析孕前BMI与妊娠期高血压疾病的相关性。
      结果 5组孕妇年龄、身高、孕次及产次等比较差异均无统计学意义(P>0.05);5组孕妇分娩时间、分娩方式比较差异有统计学意义(P < 0.05);妊娠期高血压疾病的发病率随孕前BMI升高而升高(P < 0.05);孕前超重、Ⅰ度肥胖及Ⅱ度肥胖孕妇妊娠期高血压疾病的发病风险增高(P < 0.05),Ⅱ度肥胖组孕妇发生妊娠期高血压、子痫前期、重度子痫前期的风险高于其他组,分别是正常体质量孕妇的5.19、8.77、7.97倍。孕前超重及肥胖的相对危险度>1,95%CI: 不包括1,孕前BMI≥24 kg/m2是妊娠期高血压疾病的危险因素。
      结论 孕前超重和肥胖是妊娠期高血压疾病的危险因素,应加强对育龄期妇女尤其是超重和肥胖女性孕前及孕期的体质量管理。

       

      Abstract:
      Objective To investigate the pre-pregnancy body mass distribution of pregnant women and to analyze the correlation between pre-pregnancy body mass index (BMI) and hypertensive disorders in pregnancy.
      Methods Clinical data were collected from 2 618 full-term singleton pregnant women.According to the pre-pregnancy BMI, they were divided into 234 cases in the low body mass group, 1 610 cases in the normal body mass group, 545 cases in the over group, 128 cases in the Ⅰ-degree obese group, and 101 cases in the Ⅱ-degree obese group.The general information and maternal conditions of pregnant women in the 5 groups were compared, and the correlation between pre-pregnancy BMI and hypertensive disorders in pregnancy were analyzed.
      Results There was no statistically significant difference in the age, height, pregnancy, and delivery of pregnant women in the 5 groups (P>0.05).There was a statistically significant difference in the number of days of delivery and mode of delivery of pregnant women in the 5 groups (P < 0.05).The incidence of hypertensive disorders of pregnancy increased with the increase of pre-pregnancy BMI (P < 0.05).The risk of hypertensive disorders of pregnancy increased in pregnant women with pre-pregnancy overweight, Ⅰ-degree obesity and Ⅱ-degree obesity (P < 0.05), and the risk of pregnancy hypertension, preeclampsia, and severe preeclampsia in the Ⅱ-degree obese group was higher than that in the other groups, which was 5.19, 8.77 and 7.97 times higher than that of normal-weight pregnant women, respectively.The relative risk of pre-pregnancy overweight and obesity was >1, the 95%CI did not include 1, and pre-pregnancy BMI ≥24 kg/m2 was a risk factor for hypertensive disorders in pregnancy.
      Conclusions Pre-pregnancy overweight and obesity are risk factors for hypertensive disorders in pregnancy, and weight management should be strengthened for women of childbearing age, especially overweight and obese women, before and during pregnancy.

       

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