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    基线18F-FDG PET/CT代谢参数对侵袭性非霍奇金淋巴瘤的治疗反应和预后的作用

    Role of baseline 18F-FDG PET/CT metabolic parameters in the treatment response and prognosis of invasive non-Hodgkin's lymphoma

      摘要
    • 摘要:
      目的 探讨基线18氟氟代脱氧葡萄糖-正电子发射计算机断层显像(18F-FDG PET/CT)代谢参数对侵袭性非霍金淋巴瘤(NHL)的治疗反应和预后的作用。
      方法 回顾性分析101例侵袭性NHL病人的临床资料，所有病人均接受CHOP样方案化疗及18F-FDG PET/CT检查，根据治疗反应将病人分为完全反应组63例、部分反应组22例和无反应组16例，另根据预后将病人分为预后良好组66例、预后不良组35例，比较不同治疗反应、预后病人基线18F-FDG PET/CT代谢参数最大标准化摄取值(SUVmax)、肿瘤代谢体积(MTV)、总糖酵解量(TLG)，采用受试者工作特征曲线(ROC)分析基线18F-FDG PET/CT代谢参数联合检测对侵袭性NHL治疗反应和预后的预测价值。
      结果 不同治疗反应侵袭性NHL病人基线SUVmax、MTV、TLG水平存在明显差异(F=37.38、22.20、17.16，P < 0.05)；其中，完全反应组、部分反应组基线SUVmax、MTV、TLG水平低于无反应组，且完全反应组水平低于部分反应组水平(P < 0.05)。预后良好组基线SUVmax、MTV、TLG水平低于预后不良组(t=6.49、6.02、5.48，P < 0.05)。ROC曲线显示，基线SUVmax、MTV、TLG对侵袭性NHL治疗反应和预后具有一定预测价值(AUC=0.791、0.792、0.797，0.792、0.790、0.791，P < 0.01)，且联合检测(AUC=0.853、0.846，P < 0.01)预测价值较高。
      结论 联合检测基线SUVmax、MTV、TLG等18F-FDG PET/CT代谢参数对侵袭性NHL治疗反应和预后具有较高预测价值。

       

      Abstract:
      Objective To explore the role of baseline 18fluorfluoride deoxyglucose-positron emission tomography/computed tomography(18F-FDG PET/CT) metabolic parameters on the treatment response and outcome of invasive non-Hodgkin′s lymphoma(NHL).
      Methods The clinical data of 101 patients with invasive NHL were retrospectively analyzed. All patients received chemotherapy with the R-CHOP regimen and 18F-FDG PET/CT examination. According to the treatment response, the patients were divided into the complete response group(63 cases), partial response group(22 cases) and non-response group(16 cases), In addition, according to the prognosis, the patients were divided into the good prognosis(66 cases) and poor prognosis(35 cases). The treatment response and baseline 18F-FDG PET/CT metabolic parametersincluding the maximum standardized uptake value(SUVmax), tumor metabolic volume(MTV) and total glycolysis(TLG) were compared among all groups. The predictive value of the baseline 18F-FDG PET/CT metabolic parameters on treatment response and outcome of invasive NHL were analyzed using the receiver operating characteristic (ROC) curve.
      Results The differences of the baseline SUVmax, MTV, and TLG among the invasive NHL patients with different treatment response were statistically significant(F=37.38, 22.20 and 17.16, P < 0.05). The baseline SUVmax, MTV, and TLG in complete response group and partial response group were lower than those in non-response group, and which in the complete response group was lower than that in partial response group(P < 0.05). The baseline SUVmax, MTV, and TLG levels in the good prognosis group were lower than those in poor prognosis group(t=6.49, 6.02 and 5.48, P < 0.05). The results of ROC curve showed that the baseline SUVmax, MTV, and TLG had high predictive value for treatment response and prognosis of invasive NHL(AUC=0.791, 0.792, 0.797, 0.792, 0.790, 0.791, P < 0.01), and the predictive value of combined detection was higher(AUC=0.853, 0.846, P < 0.01).
      Conclusions The 18F FDG-PET/CT) metabolic parameters(combined detection baseline SUVmax, MTV, TLG) have high predictive value on the treatment response and prognosis of invasive NHL.

       

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