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    PLOD2、Snail和Slug在食管鳞状细胞癌中的表达及其临床意义

    Expressions of PLOD2, Snail and Slug in esophageal squamous cell carcinoma and their clinical significance

      摘要
    • 摘要:
      目的 研究食管鳞状细胞癌中PLOD2、Snail和Slug的表达情况。
      方法 采用免疫组织化学ElivisionTM plus法检测120例食管鳞状细胞癌、40例食管鳞状上皮非典型增生(中、重度)和40例正常食管鳞状上皮的PLOD2、Snail和Slug表达情况, 分析三种标志物的表达与各临床病理因素和病人的生存预后之间的关系；以及PLOD2与EMT相关因子Snail和Slug的关系, 探索PLOD2在EMT中的作用。
      结果 从正常食管鳞状上皮到非典型增生和食管鳞状细胞癌, PLOD2、Slug和Snail的表达逐渐明显上升(P < 0.01)；同时PLOD2、Snail和Slug的表达与肿瘤的浸润深度、分化程度、临床分期以及淋巴结转移有关(P < 0.01)。另外, PLOD2与Snail、和Slug的表达均成正相关关系(r=0.812, r=0.759, P < 0.01), Snail与Slug的表达成正相关关系(r=0.882, P < 0.01)。同时, 生存分析显示，PLOD2、Snail和Slug阳性表达组5年生存率明显低于阴性表达组(P < 0.01)。
      结论 PLOD2、Snail和Slug的表达与食管鳞状细胞癌的发生发展和预后有关, 联合检测其表达情况可能对食管鳞状细胞癌的进展及预后判断有重要意义。

       

      Abstract:
      Objective To explore the expression of PLOD2, Snail and Slug in esophageal squamous cell carcinoma.
      Methods The expressions of PLOD2, Snail and Slug in 120 specimens of esophageal squamous cell carcinoma, 40 specimens of atypical hyperplasia of esophageal squamous epithelium (moderate and severe) and 40 specimens of normal mucosa were detected by immunohistochemical staining.The relationships between the expressions of the three proteins and the clinicopathological features, survival time and survival state of the patients were analyzed.The relationship between PLOD2 and the EMT-associated factors Snail and Slug was analyzed and the role of PLOD2 in EMT was explored.
      Results From normal esophageal squamous epithelium to atypical hyperplasia and esophageal squamous cell carcinoma, the expressions of PLOD2, Slug and Snail increased gradually (P < 0.01).The expressions of PLOD2, Snail and Slug were related to the depth of tumor invasion, differentiation, clinical stage and lymph node metastasis (P < 0.01).In addition, expression of PLOD2 was positively correlated with the expression of Snail and Slug (r=0.812 and 0.759, P < 0.01), the expression of Snail was also positively correlated with expression of Slug (r=0.882, P < 0.01).The 5-year survival rate of PLOD2, Snail and Slug positive expression group were significantly lower than that of the negative expression group(P < 0.01).
      Conclusions The expressions of PLOD2, Snail and Slug are related to the occurrence, development and prognosis of esophageal squamous cell carcinoma.The combined detection of their expressions maybe has great significance to the progress and prognosis of esophageal squamous cell carcinoma.

       

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