Abstract: Objective: To explore the risk factors for rebleeding in patients with (AUGIB). Methods: A retrospective analysis was conducted on the clinical data of 50 patients with AUGIB,who were divided into a rebleeding group and a non-rebleeding group based on whether they experienced rebleeding.The clinical data of the two groups of patients were analyzed to explore the risk factors for rebleeding. Results: Among AUGIB patients,there were 12 cases (24%) in the rebleeding group and 38 cases (76%) in the non-rebleeding group,with a male to female ratio of 3.5∶1.There were 30 cases of peptic ulcer.There were statistically significant differences in vomiting blood,proportion of neutrophils,red blood cell distribution width,platelets,albumin,prothrombin time,activated partial thromboplastin time,thrombin time,fibrinogen,and plasma D-dimer between the two groups (P<0.05 to P<0.01).Logistic regression analysis showed that D-Dimer (OR:0.994,95%CI:0.989-1.000) and platelets (OR:1.066,95%CI:0.994-1.144) were independent risk factors for rebleeding in AUGIB patients. Conclusions: AUGIB is more common in males,and gastrointestinal ulcers with bleeding are the most common.Platelet and plasma D-dimer levels are independent risk factors for rebleeding.