Abstract: Objective: To investigate the detection rate and influencing factors of fundus disease in newborns in Yingzhou district of Fuyang city. Methods: A total of 15 283 newborns,who were screened for fundus lesions,were divided into the full-term group(11 692 cases) and preterm group(3 591 cases) according to the gestational age.The detection rate of neonatal fundus disease was compared between two groups,and the influencing factors of neonatal retinal hemorrhage were analyzed. Results: The difference of the total detection rate of fundus disease was statistically significant between two groups(P<0.01).The highest detection rate of fundus diseases in two groups was retinal hemorrhage,and the difference in detection rate of which between two groups was statistically significant(P<0.01).The results of univariate and multivariate logistic regression analysis showed that the gestational age,delivery mode,birth weight and maternal complications during pregnancy were the influencing factors of the occurrence of neonatal retinal hemorrhage(P<0.05 to P<0.01).The differences of the total detection rate of retinopathy of prematurity in newborns with different gestational age and birth weight were statistically significant(P<0.01). Conclusions: In Yingzhou district of Fuyang city,the detection rate of retinal hemorrhage and other fundus diseases in newborns is high.The gestational age,delivery mode,birth weight and maternal complications during pregnancy are the independent influencing factors of the occurrence of retinal hemorrhage in newborns.