高级检索

    血清肿瘤标志物CA125、CA199、CA72-4、CEA联合检测在胃肠道肿瘤中的应用价值

    Application value of combined detection of serum tumor markers CA125, CA199, CA72-4 and CEA in gastrointestinal tumors

      摘要
    • 摘要:
      目的 探讨血清肿瘤标志物糖类抗原125(CA125)、糖类抗原199(CA199)、糖类抗原72-4(CA72-4)及癌胚抗原(CEA)联合检测在胃肠道肿瘤中的应用价值。
      方法 随机选取158例胃肠道肿瘤病人(观察组)与46例胃肠道良性病变病人(对照组)的临床资料进行回顾性分析，检测2组CA125、CA199、CA72-4、CEA并进行统计学分析，评估CA125、CA199、CA72-4、CEA在胃肠道肿瘤病人中的应用价值。
      结果 观察组CA125、CA199、CA72-4、CEA水平均明显高于对照组(P < 0.01)；在不同病理分化类型的胃肠道肿瘤中CA125、CA199、CA72-4、CEA水平由低到高为高分化腺癌 < 中分化腺癌 < 低分化腺癌，差异有统计学意义(P < 0.05~P < 0.01)；有淋巴结转移的胃肠道肿瘤CA125、CA199、CA72-4、CEA水平高于无淋巴结转移(P < 0.05~P < 0.01)；CA125、CA199、CA72-4、CEA联合检测诊断胃肠道肿瘤的AUC均高于上述四项指标单独检测诊断，差异有统计学意义(P < 0.01)。
      结论 对胃肠道肿瘤病人进行CA125、CA199、CA72-4、CEA联合检测，可为临床医生诊断胃肠道肿瘤提供依据，同时也能较为准确地分析其病情，有利于了解肿瘤的病理分化和有无淋巴结转移。

       

      Abstract:
      Objective To explore the application value of combined detection of serum tumor markers carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199), carbohydrate antigen 72-4 (CA72-4), and carcinoembryonic antigen (CEA) in gastrointestinal tumors.
      Methods Clinical data of 158 patients with gastrointestinal tumors (observation group) and 46 patients with benign gastrointestinal lesions (control group) were randomly selected for retrospective analysis.CA125, CA199, CA72-4, and CEA were detected in the two groups and statistically analyzed to evaluate the application value of CA125, CA199, CA72-4, and CEA in patients with gastrointestinal tumors.
      Results The levels of CA125, CA199, CA72-4, and CEA in the observation group were significantly higher than those in the control group (P < 0.01).The levels of CA125, CA199, CA72-4, and CEA in gastrointestinal tumors of different pathological differentiation types were as follows: well differentiated adenocarcinoma < moderately differentiated adenocarcinoma < poorly differentiated adenocarcinoma, with statistically significant differences (P < 0.05 to P < 0.01).The levels of CA125, CA199, CA72-4, and CEA in gastrointestinal tumors with lymph node metastasis were higher than those without lymph node metastasis (P < 0.05 to P < 0.01).The AUC of the ROC curve for the combined detection of CA125, CA199, CA72-4, and CEA in the diagnosis of gastrointestinal tumors was higher than that of the individual detection of the above four indicators, and the difference was statistically significant (P < 0.01).
      Conclusions The combined detection of CA125, CA199, CA72-4, and CEA in patients with gastrointestinal tumors can provide a basis for clinical diagnosis of gastrointestinal tumors, and can also accurately analyze their condition, which is beneficial for understanding the pathological differentiation and lymph node metastasis of tumors.

       

      • HTML全文
      • 参考文献(15)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回