Abstract: Objective: To investigate the value of serum pepsinogen Ⅰ(PGⅠ),pepsinogen Ⅱ(PGⅡ),PGⅠ/PGⅡ ratio(PGR),gastrin-17(G17) and Helicobacter pylori(Hp) antibody typing in the diagnosis of chronic atrophic gastritis(CAG). Methods: A total of 170 patients with chronic gastritis were divided into the CAG group(79 cases) and chronic non-atrophic gastritis(CNAG) group(91 cases).The changes of indicators were compared between two groups. Results: Ninety-two cases(54.12%) of 170 patients were positive for Hp.Compared with the control group,the Hp antibody positive rate,infection positive rate of type Ⅰ Hp,PGⅡ and G17 levels significantly increased(P<0.05 to P<0.01),while the PGR level decreased in the CAG group(P<0.01).Compared with type Ⅱ Hp positive group,the expression levels of PGⅡ and G17 increased,while the PGR level decreased in the type Ⅰ Hp positive group(P<0.05).The AUC of PGⅠ,PGⅡ,PGR,G17 and Hp antibody typing were 0.548,0.606,0.361,0.660 and 0.589,respectively.The AUC of combined detection was 0.690. Conclusions: The level changes of PGⅡ,PGR,G17 and Hp antibody type can be used as the screening indicators of CAG,and the combined detection can provide a more reliable laboratory basis for clinical diagnosis and treatment.