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    慢性萎缩性胃炎病人幽门螺杆菌感染特征及胃功能状态评估研究

    Study on the characteristics of Helicobacter pylori infection and gastric function status in patients with chronic atrophic gastritis

      摘要
    • 摘要:
      目的 探讨血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、PGⅠ/PGⅡ比值(PGR)、胃泌素-17(G-17)与幽门螺旋杆菌(Hp)抗体分型检测在慢性萎缩性胃炎(CAG)诊断中的应用价值。
      方法 选取170例慢性胃炎病人，其中CAG组79例，慢性非萎缩性胃炎(CNAG) 91例，比较2组指标的变化。
      结果 170例病人中Hp阳性92例，阳性率54.12%。与CNAG组比较，CAG组Hp抗体阳性率、Ⅰ型Hp感染阳性率、PGⅡ和G17水平均明显升高(P < 0.05~P < 0.01)，PGR水平降低(P < 0.01)。Ⅰ型Hp阳性组与Ⅱ型Hp阳性组相比，PGⅡ和G17的表达水平升高(P < 0.05)，PGR水平降低(P < 0.05)。PGⅠ、PGⅡ、PGR、G17和Hp抗体分型的AUC分别为0.548、0.606、0.361、0.660、0.589；联合检测的AUC为0.690。
      结论 PGⅡ、PGR、G17水平变化及Hp抗体分型可作为萎缩性胃炎筛查指标，联合检测可为临床诊疗提供更可靠的实验室依据。

       

      Abstract:
      Objective To investigate the value of serum pepsinogen Ⅰ(PGⅠ), pepsinogen Ⅱ(PGⅡ), PGⅠ/PGⅡ ratio(PGR), gastrin-17(G17) and Helicobacter pylori(Hp) antibody typing in the diagnosis of chronic atrophic gastritis(CAG).
      Methods A total of 170 patients with chronic gastritis were divided into the CAG group(79 cases) and chronic non-atrophic gastritis(CNAG) group(91 cases).The changes of indicators were compared between two groups.
      Results Ninety-two cases(54.12%) of 170 patients were positive for Hp.Compared with the control group, the Hp antibody positive rate, infection positive rate of type Ⅰ Hp, PGⅡ and G17 levels significantly increased(P < 0.05 to P < 0.01), while the PGR level decreased in the CAG group(P < 0.01).Compared with type Ⅱ Hp positive group, the expression levels of PGⅡ and G17 increased, while the PGR level decreased in the type Ⅰ Hp positive group(P < 0.05).The AUC of PGⅠ, PGⅡ, PGR, G17 and Hp antibody typing were 0.548, 0.606, 0.361, 0.660 and 0.589, respectively.The AUC of combined detection was 0.690.
      Conclusions The level changes of PGⅡ, PGR, G17 and Hp antibody type can be used as the screening indicators of CAG, and the combined detection can provide a more reliable laboratory basis for clinical diagnosis and treatment.

       

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