Abstract:
Objective To explore the impact of surgical treatment as the main treatment method and radical radiotherapy as the main treatment on the survival rate and quality of life of patients with mid-late oral cancer.
Methods A retrospective analysis was conducted on the data of oral cancer patients admitted to three tertiary comprehensive hospitals in the province from 2015 to 2020.Patient information was improved through imaging, pathological data, and follow-up results.A total of 1 123 patients with mid-late oral cancer were screened according to inclusion and exclusion criteria.The screening subjects were divided into radical surgical treatment group (ST group) and radical radiotherapy group (RT group).Kaplan-Meier and Log-rank were used to calculate and compare overall survival rate and survival rate of two treatment methods.A UW-QOL (4) questionnaire was used to self-evaluate the quality of life of tumor free survivors, and statistical analysis was used to compare the survival rate and quality of life of two treatment methods.
Results The overall survival rates of patients at 1, 3, and 5 years were 84.0%, 66.4%, and 54.0%, respectively.There were 757 cases in the ST group and 366 cases in the RT group, and the survival rate of ST group was significantly higher than that of the RT group (P < 0.05).The average total score of quality of life in the ST group was significantly higher than that in the RT group (P < 0.05) between the two groups who received questionnaires.
Conclusions Radical surgery as the main treatment method, preoperative induction chemotherapy, postoperative low-dose radiotherapy, or postoperative adjuvant chemotherapy have better survival rates and quality of life compared to radical radiotherapy as the main treatment method.The first choice for the treatment of mid-late oral cancer should be surgical treatment as the main approach, with preoperative/postoperative adjuvant low-energy chemotherapy/radiotherapy.
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