Abstract: Objective: To analyze the risk factors of white matter lesions(WML) in different parts of brain in elderly patients,and correlation between carotid intima-media thickness(CIMT),homocysteine(Hcy) level and WML in different parts of brain. Methods: The head magnetic resonance imaging(MRI) data of 363 patients with dizziness as the main complaint or accompanied by dizziness were collected,and the WML scores of different parts were obtained.The results of carotid ultrasonography and other relevant clinical data were collected.The independent risk factors of WML in different locations were analyzed using logistic regression analysis. Results: The age and hypertension were the common risk factors of deep white matter lesions(d-WML) and paraventricular white matter lesions(p-WML),but the Hcy and CIMT were only the independent risk factors of d-WML,and the male and TG were the independent risk factors of p-WML(P<0.05).The risk factors of d-WML and p-WML were different. Conclusions: The influencing factors of WML in different parts of elderly patients are different.The CIMT and Hcy may be related to the occurrence and development of deep WML in elderly patients,while the age and hypertension are the common independent risk factors of d-WML and p-WML.