Abstract: Objective: To explore the effects of high-intensity interval training(HIIT) and moderate-intensity continuous training (MICT) in home-based cardiac rehabilitation for patients with coronary heart disease. Methods: A total of 100 patients with coronary heart disease were selected and randomly divided into HIIT group (n=50) and MICT group (n=50).Both groups of patients underwent continuous training for 6 months.The left ventricular ejection fraction (LVEF),left ventricular end-diastolic diameter (LVEDD),and left ventricular end-systolic diameter (LVESD) were compared before and after rehabilitation training in both groups of patients.The distance of the 6-minute walk test (6-MWT) before and after intervention,as well as the maximum heart rate (HRmax),maximum oxygen uptake (VO₂max),and systolic blood pressure (SBP) before and after intervention were compared between the two groups of patients.The quality of life of patients before and after rehabilitation exercise was evaluated using the short form-36 health survey (SF-36).The major adverse cardiac events of the two groups of patients within 6 months after rehabilitation exercise were compared. Results: After rehabilitation training,both groups of patients showed an increase in LVEF and LVEDD,and a decrease in LVESD compared to before rehabilitation training (P<0.05).After rehabilitation training,LVEF and LVEDD in HIIT group were higher than those in MICT group (P<0.05).After one month of intervention,the 6-MWT scores of patients in the MICT and HIIT groups were higher than those before intervention,and six months after intervention,the 6-MWT scores of patients in the MICT and HIIT groups were higher than those before intervention and one month after intervention,with statistically significant differences (P<0.05).After 1 and 6 months of intervention,the 6-MWT scores of patients in the HIIT group were higher than those in the MICT group,with statistically significant differences (P<0.05 to P<0.01).After rehabilitation training,VO₂max was higher than before rehabilitation training,while HRmax and SBP were lower than before rehabilitation training (P<0.01).The VO₂max of patients in the HIIT group was higher than that in the MICT group,while SBP was lower than that in the MICT group (P<0.05).After rehabilitation training,the scores of each dimension of SF-36 in the MICT group and HIIT group were higher than those before rehabilitation training (P<0.05),and the scores of each dimension of SF-36 in the HIIT group were higher than those in the MICT group (P<0.05 to P<0.01).There was no significant difference in the incidence of adverse cardiac events such as arrhythmia,angina,heart failure,and vascular blockage between the two groups of patients within 6 months after cardiac rehabilitation training (P>0.05). Conclusions: Compared with MICT,HIIT is more effective in improving the heart function and cardiopulmonary exercise capacity of patients with coronary heart disease in home-based cardiac rehabilitation,and improving exercise endurance and quality of life.