Abstract: Objective: To analyze the influencing factors of the related symptoms cluster of living activity function in esophageal cancer patients treated with concurrent radiotherapy and chemotherapy. Methods: A total of 112 esophageal cancer patients treated with concurrent radiotherapy and chemotherapy,and the related symptom cluster factors were analyzed by SPSS26.0 statistical software. Results: Among the 120 patients,112 patients finally completed the survey(93.33%),and the six symptoms of tested patients were the dry mouth,pain,nausea,vomiting,poor appetite and sleep disturbance.The results of exploratory factor analysis showed that the three symptom clusters were vomiting and nausea,poor appetite and fatigue,dry mouth and pain.The symptom groups were extracted by principal component analysis.The KMO test(KMO=0.89) and Bartlett sphericity test(χ²=1 235.43,df=55,P<0.01) showed that there was a correlation among the data,which was suitable for principal component analysis.The results of multiple linear regression showed that the number of radiotherapy,number of complications and stage of disease were the main factors affecting the related symptom of life activity.The determination coefficient of the three variables were R²=0.164,correction R²=0.150 and F=11.270(P<0.01). Conclusions: There are several related symptom clusters affecting living activity function in esophageal cancer patients treated with concurrent radiotherapy and chemotherapy.Medical staff should correctly understand the impact of symptom cluster on patients,and carry out targeted intervention measures to improve the body and economic burden of patients.